Method and compositions for overcoming tetracycline resistance w

Details Method and compositions for overcoming tetracycline resistance w Method and compositions for overcoming tetracycline resistance w

1990-02-26

1991-11-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

424114, A01N 3718, A61K 3500

Patent

active

050648217

ABSTRACT:
The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs 13-(substituted mercapto) derivatives of tetracycline in combination with other tetracycline-type antibiotics as a synergistic combination of compositions to be administered simultaneously or concurrently. The concomittantly administered compositions effectively overcome the tetracycline resistant mechanisms present such that the cell is effectively converted from a tetracycline-resistant state to a tetracycline-sensitive state. The combination also effects a synergistic bacteriocidal activity against susceptible and resistant cells.

REFERENCES:
patent: 3236736 (1966-02-01), Fitch et al.
patent: 3454697 (1969-07-01), Joyner et al.
patent: 3863009 (1975-01-01), Johnston

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