Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-02-22
1997-03-25
Ketter, James S.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435325, 435355, C12N 1585, C12N 510
Patent
active
056143974
ABSTRACT:
Methods and compositions for modifying the lifespan of progeny cells of mammalian hematopoietic stem cells, particularly myeloid series cells, are provided. Transgenic nonhuman mammals also are provided which produce transgenic myeloid cells having an altered lifespan.
REFERENCES:
Hockenberry et al., "Bcl-2 Functions in an Antioxidant Pathway to Prevent Apoptosis," Cell (1993) 75:241-251.
Ellis et al., "Genetic Control of Progammed Cell Death in the Nematode C. elegans," Cell (1986) 44:817-829.
Hengartner, M.O., "Caenorhabditis elegansgene ced-9 protects cells from programmed cell death," Nature (1992) 356:494-499.
Nakayama et al., "Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice," Science (1993) 261:1684.
Snouwaert et al., "An Animal Model for Cystic Fibrosis Made by Gene Targeting," Science (1992) 257:1083-1088.
Dorin et al., "Cystic fibrosis in the mouse by targeted insertional mutagenesis, " Nature (1992) 359:211-215.
Lagasse et al., "Cloning and Expression of Two Human Genes Encoding Calcium-Binding Proteins That Are Regulated During Myeloid Differentiation," Mol. Cell. Biol. (1988) 8:2402-2410.
Lagasse et al., "Mouse MRP8 and MRP14, Two Intracellular Calcium-Binding Proteins Associated with the Development of the Myeloid Lineage," Blood (1992) 79:1907.
Spencer et al., "Controlling Signal Transduction with Synthetic Ligands," Science (1993) 262:1019-1024.
Porter et al., "X-Linked Chronic Granulomatous Disease: Correction of NADPH Oxidase Defect by Retrovirus-Mediated Expression of gp91-phox," Blood (1993) 82:2196-2202.
Cobbs et al., "Retroviral Expression of Recombinant p47.sup.phox Protein by Epstein-Barr Virus-Transformed B Lyphocytes From a Patient With Autosomal Chronic Granulomatous Disease," Blood (1992) 79:829-1835.
Erikson et al., "Identification of a Thermolabile Component of the Human Neutrophil NADPH Oxidase," J. Clin. Invest. (1992) 89:1587-1595.
DiBartolomeo et al., "Reconstitution of normal neutrophil function in chronic granulomatous disease by bone marrow transplantation," Bone Marrow Transplantation (1989) 4:695-750.
Lomax et al., "Selective Defect in Myeloid Cell Lactoferrin Gene Expression in Neutrophil Specific Granule Deficiency," J. Clin. Invest. (1989) 83:514-519.
Veis et al., "Bcl-2-Deficient Mice Demonstrate Fulminant Lymphoid Apoptosis, Polycystic Kidneys, and Hypopigmented Hair," Cell (1993) 75:229.
Bright et al., Biosciences Reports, vol. 14, 1994, pp. 67-81.
Nowicki et al., Cellular Immunology, vol. 132, 1991, pp. 115-126.
Sarin et al., J. Experimental Medicine, vol. 178, 1993, pp. 1693-1700.
Gong et al., J. Cellular Phyriology, vol. 157, 1993, pp. 263-270.
Lagasse Eric
Weissman Irving
Board of Trustees of the Leland Stanford Junior University
Bozicevic Karl
Conley Deirdre L.
Ketter James S.
LandOfFree
Method and compositions for modulating lifespan of hematolymphoi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and compositions for modulating lifespan of hematolymphoi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for modulating lifespan of hematolymphoi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2202461