Method and compositions for maintaining glomerular filtration ra

Details Method and compositions for maintaining glomerular filtration ra Method and compositions for maintaining glomerular filtration ra

1994-07-25

1996-04-30

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514300, A61K 3144

Patent

active

055125808

ABSTRACT:
This invention provides a method of and compositions for increasing or maintaining glomerular filtration rate while preserving renal structure in a patient comprising administering an angiotensin II type 1 vascular receptor antagonist to the patient, independent of its effects on systemic blood pressure. The invention provides that, by administering the AII type 1 receptor antagonist, blood flow to the kidney can be improved without sacrificing intraglomerular pressure and therefore glomerular filtration and that even with this enhanced glomerular pressure and filtration, renal structure is preserved. Also provided is a method of screening AII type 1 receptor antagonists for the ability to maintain or increase glomerular filtration rate while decreasing mesangial matrix accumulation comprising the steps of administering the antagonist in an animal model characterized by decreased glomerular filtration rate and increased mesangial matrix accumulation and selecting the compounds that increase glomerular filtration rate while decreasing mesangial matrix accumulation.

REFERENCES:
Takeda, et al. Kidney International, 42:1713-1719, 1992.
Fogo et al. Kidney International 42:770-774, 1992.
Awazu et al. J. Amer Soc. Nephrology, 1:1253-1258, 1991.
Kon and Badr Kidney International, 40:1-12, 1991.
Kon et al. Kidney International. 37:1487-1491, 1990.
Chang et al., FASEB J. 5 (Part III): 6993 (Abstr) 1991 Cited by Applicants p. 18, Applicants Should Provide a copy of this reference.

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