Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-12-13
2010-12-07
Bowman, Amy (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C536S024500
Reexamination Certificate
active
07846909
ABSTRACT:
Method for inhibiting tumor cell formation or tumor cell growth, and method for inducing apoptosis in sperms, the method comprising administering to a patient in need thereof an antagonist that inhibits the binding of MAGE protein to KAP-1, thereby inhibiting MAGE gene function. Also disclosed are pharmaceutical compositions comprising the same, and method for screening a substance that inhibits MAGE protein binding to KAP-1.
REFERENCES:
Monte et al., MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents, Jul. 2006, PNAS, vol. 103, No. 30, pp. 11160-11165.
Longley B. Jack
Ma Yongsheng
Wu Jianqiang
Yang Bing
Bowman Amy
Li Kening
Pinsent Masons LLP
Wisconsin Alumni Research Foundation
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