Method and compositions for detecting hematopoietic tumors

Details Method and compositions for detecting hematopoietic tumors Method and compositions for detecting hematopoietic tumors

1995-11-15

1998-11-24

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, C12Q 168

Patent

active

058404929

ABSTRACT:
Methods and compositions for the diagnosis and prognosis of hematopoietic tumors, such as T-cell acute lymphoblastic leukemia, in a human. The invention relates to using nucleic acid hybridization probes to detect, by fluorescent in situ chromosome hybridization, deletion of tal-1 locus on chromosome 1 from human cells to confirm T-cell acute lymphoblastic leukemia in the patient.

REFERENCES:
Hopman et al, Histochemistry, 85 (1986):1-4.
Chen et al, Enbo J, v. 9, 1990, pp. 415-424.
Suske et al, Nucleic Acidv Rev. v. 17, 1989, p. 4405.

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