Method and composition for treatment of disorders involving immu

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

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4241461, 424 946, 514 2, 514825, 435194, 436506, 436507, 436508, 436509, 536 11, A61K 3900, A61K 39395, A61K 3800, G01N 33564

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active

058041885

ABSTRACT:
A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein or a derivative thereof to a human or animal with an immune dysfunction disorder.

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McNeilage, L.J. et al., "Review: Autoantibodies Reactive with Small Ribonucleoprotein Antigens: A Convergence of Molecular Biology Clinical Immunology," J. Clin. Lab. Immunol., vol. 15, pp. 1-17, (1984).
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Stetler et al., "Immunization of Rabbits with Purified RNA Polymerase I Induces A Distinct Population of Antibodies Against Nucleic Acids As Well As Anti-RNA Polymerase I Antibodies Both Characteristic of Systematic Lupus Erythematosus," PNAS, vol. 82, pp. 6797-6801 (Oct. 1985).
Reimer et al., "Autoantibody to RNA Polymerase I in Scleroderma Sera," J. Clin. Invest., vol. 79, pp. 65-72 (Jan. 1987).
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