Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-12
2000-01-11
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 530317, 530402, A61K 3800
Patent
active
060136251
ABSTRACT:
The invention provides RGD containing peptides which are cyclized and contain hydrophobic moieties adjacent the carboxy terminus of the RGD sequence. Such peptides have an high affinity for the receptor IIb/IIIa and low affinity for the fibronectin and vitronectin receptors. Such peptides can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis.
REFERENCES:
patent: 4517666 (1985-05-01), Hideo
patent: 4547489 (1985-10-01), Goldstein
patent: 4578079 (1986-03-01), Ruoslahit et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4605512 (1986-08-01), Schaller et al.
patent: 4614517 (1986-09-01), Ruoslahti
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4789734 (1988-12-01), Pierschbacher
patent: 4792525 (1988-12-01), Ruoslahti
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4929601 (1990-05-01), Brunetti et al.
patent: 4943562 (1990-07-01), Jolles et al.
patent: 5023233 (1991-06-01), Nutt et al.
patent: 5037808 (1991-08-01), Adams et al.
patent: 5041380 (1991-08-01), Ruoslahti
patent: 5066592 (1991-11-01), Huang et al.
patent: 5612311 (1997-03-01), Pierschbacheret al.
patent: 5643872 (1997-07-01), Ali et al.
patent: 5648330 (1997-07-01), Pierschbacher et al.
patent: 5672585 (1997-09-01), Pierschbacher et al.
Kopple et al., "Conformations of Arg-Gly-Asp Containing Heterodetic Cyclic Peptides: Solution and Crystal Studies", J. Am. Chem. Soc., 114: 9615-9623, (1992).
Gougos and Letarte, "Primary Structure of Endoglin, an RDG-containing Glycoprotein of Human Endothelial Cells", J. Biol. Chem., 265(15):8361-8364 (1990).
Wright et al., C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp, PNAS, USA, 84:1965-1968 (1987).
Gehlsen et al., J. Cell. Biol. 106:925-930 (1988).
Gehlsen et al., J. Cell. Biol. 105:3097-3104 (1987).
Siebers et al., Eur. J. Biochem. 178:131-140 (1988).
Ruoslahti et al., Cell 44:517-518 (1986).
Ruoslahti et al., Falk Symposium 43:239-244 (1987).
Bodanszky, Principles of Peptide Synthesis 217-222 (1984).
Marx, Science 248:1491-1493 (1990).
Creighton, Proteins 9 (1984).
Dayhoff, Atlas of Protein Sequences and Structure 5:89-99 (1972).
Joubert et al., Biochim. Biophys. Acta. 579:228-233 (1979).
Gan et al., J. Biol. Chem. 263(36):19827-19832 (1988).
Huang et al., J. Biol. Chem. 262(33):16157-16163 (1987).
Pelton et al., Proc. Natl. Acad. Sci. USA 82:236-239 (1985).
Sakakibara et al., BBA 303:198-202 (1973).
Kaiser and Kezcy, Science 223:249-255 (1984).
Ohsaku et al., Int. J. Biol. Macromol. 6:234-240 (1984).
Cheresh, Chem. Abstract 104, abstract No. 183980c (1986).
Yamada, Chem. Abstract 107, abstract No. 5066p (1987).
Poole, Chem. Abstract 105, abstract No. 169400c (1986).
Toda et al., J. Cell. Biol. 105:3097-3104 (1987).
Singer et al., J. Cell. Biol. 104:573-584 (1987).
Lash et al., Dev. Biol. 123:411-420 (1987).
Pierschbacher and Ruoslahti, J. Biol. Chem. 262:17294-17298 (1987).
Haverstick et al., Blood 66:946-952 (1985).
Ruggeri et al., Proc. Natl. Acad. Sci. USA 83:5708-5712 (1986).
Ginsberg et al., J. Biol. Chem. 260:3931-3936 (1985).
Pierschbacher et al., Proc. Natl. Acad. Sci. USA 81:5985-5988 (1984).
Kloczewisk et al., Biochemistry 23:1767-1774 (1984).
Gartner and Bennett, J. Biol. Chem. 260:11891-11894 (1985).
Kleffer and Phillips, Annu. Rev. Cell Biol. 36:329-357 (1990).
Plow et al., Proc. Natl. Acad. Sci. USA 82:8057-8061 (1985).
Pytela et al., Proc. Natl. Acad. Sci. USA 82:5766-5770 (1985).
Pytela et al., Cell 40:191-198 (1985).
Pytela et al., Science 231:1559-1562 (1985).
Gardner et al, Cell 42:439-448 (1985).
Pierschbacher et al., Nature 309:30-33 (1984).
D'Souza et al., J. Biol. Chem. 263:3943-3951 (1988).
Parise et al., J. Biol. Chem. 262:12597-12602 (1987).
Haskei et al., Thromb. Res. 56:687-695 (1988).
Plow et al., Blood 70:110-115 (1987).
Ruoslahti et al., J. Clin. Invest. 87:1-5 (1991).
Ali et al., Peptides Proc. 11th Amer. Peptide Symposium, La Jolla, CA, Marshall & Rivier, eds. (Jul. 9-14, 1989).
Garsky et al., Proc. Natl. Acad. Sci. USA 86:4022-4026 (1989).
Dennis et al., Proc. Natl. Acad. Sci. USA 87:2471-2475 (1989).
Chao et al., Proc. Natl. Acad. Sci. USA 86:8050-8054 (1989).
Shebuski et al., J. Biol. Chem. 264:21550-21556 (1989).
Huang et al., Biochemistry 28:661-666 (1989).
Spatola and Krzysztof, Tetrahedron 44(3):821-833 (1988).
Garo and Spatola, Biochem. Biophys. Res. Commun. 120(3):840-845 (1984).
Edwards and Spatola, Biochem. Biophys. Res. Commun. 136(2):730-736 (1986).
Spatola and Edwards, Biopolymers 25:s229-s244 (1986).
Davies et al., Biochem. Soc. Trans. 18:11326-11328 (1990).
Drickamer et al., J. Biol. Chem. 261:6878-6887 (1986).
Rauvala et al., J. Cell. Biol. 107:2293-2305 (1988).
Maes et al., Fed. Europ. Biochem. Soc. 241:41-45 (1988).
Moos et al., Nature 334:701-703 (1988).
Neurath et al., Mol. Immun. 27:539-549 (1990).
Kirchofer et al., J. Biol. Chem. 265:18525-18530 (1990).
Ratner et al., Nature 313:277-284 (1985).
Bond et al., Biochemistry 28:6110-6113 (1989).
Ohlstein et al., Thromb. Res. 46:576-585 (1987).
Harvey, J. Toxicol.--Toxin Reviews 3:91-137 (1984).
Dufton, CRC Crit. Rev. in Biochem. 14:113-171 (1983).
Olson, Nature 228:438-442 (1970).
Pelton, J. Med. Chem. 29:2370-2375 (1986).
Lebl, Collection Czechosloval Chem. Commun. 49:2680-2688 (1984).
Stanfield, J. Org. Chem. 51:5153-5156 (1986).
Barker, Protein Society 2nd Symposium (1987).
Pilrenbaumer, Chem Abstract #112:199131 of WO89/05150, Jun. 15, 1989.
Gehlsen et al., "Inhibition of In Vitro Tumor Cell Invasion by Arg-Gly-Asp-containing Synthetic Peptides" J. Cell. Biol. 106:925-930 (1988).
Siebers et al., "The K.sup.+ -translocating Kdp-ATPase from Escherichia coli, Purification, enzymatic properties and production of complex- and subunit-specific antisera" Eur. J. Biochem. 178:131-140 (1988).
Ruoslahti et al., "Arg-Gly-Asp: A Versatile Cell Recognition Signal" Cell 44:517-518 (1986).
Ruoslahti et al., "Arg-Gly-Asp: a cellular recognition system for positional signalling" Falk Symposium 43:239-244 (1987).
Bodansky, Principles of Peptide Synthesis 217-222 (1984).
Marx, "Holding the Line Against Heart Disease" Science 248:1491-1493 (1990).
Creighton, Proteins, Structures and Molecular Principles, Chapter 9, W.H. Freeman and Company, New York (1984).
Dayhoff et al., Chapter 9: "A Model of Evolutionary Change in Proteins", in Atlas of Protein Sequences and Structure 5:89-99 (1972).
Joubert et al., " Some Properties and the Complete Primary Structures of Two Reduced and S-Carboxymethylated Polypeptides (S5C1 and S5C10) From Dendroaspis Jamesoni Kaimosae (Jameson's Mamba) Venom" Biochim. Biophys. Acta. 579:228-233 (1979).
Gan et al., " Echistatin, A Potent Platelet Aggregation Inhibitor from the Venom of the Viper, Echis Carinatus" J. Biol. Chem. 263(36):19827-19832 (1988).
Huang et al., "Trigramin, A Low Molecular Weight Peptide Inhibiting Fibrinogen Interaction with Platelet Receptors Expressed on Glycoprotein IIb-IIIa Complex" J. Biol. Chem. 262(33):16157-16163 (1987).
Pelton et al., "Conformationally restricted analogs of somatostatin with high .mu.-opiate receptor specificity" Proc. Natl. Acad. Sci. USA 82:236-239 (1985).
Sakakibara et al., "Synthesis of (Pro-Hyp-Gly)n of defined molecular weights , Evidence for the stabilization of collagen triple helix by hydroxypyroline" BBA Report 303:198-202 (1973).
Kaiser and Kezcy, "Amphiphilic Secondary Structure: Design of Peptide Hormones" Science 223:249-255 (1984).
Ohsaku et al., "Electronic structures of collagen model polymers: (Gly-Pro)n, (Gly-Hyp)n, (Ala-Pro)n, (Ala-Hyp)n, (Gly-Pro-Gly)n, (Gly-Hyp-Gly)n, (Gly-Pro-Pro)n, and (Gly-Pro-Hyp)n" Int. J. Biol. Macromol. 6:234-240 (1984).
Cheresh, "Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins" Chem. Abstract 104, abstract No. 183980c (1986).
Yamada, "Peptide inhibitors of fibronectin, laminin, and other adhesion molecules: unique and shared features" Chem. Ab
Cheng Soan
Craig William S.
Lukeman David S.
Pierschbacher Michael D.
Delaney Patrick R.
La Jolla Cancer Research Foundation
Tsang Cecilia J.
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