Method and composition for treating thrombosis

Details Method and composition for treating thrombosis Method and composition for treating thrombosis

1995-06-05

2000-08-08

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530317, 530324, 530325, 530326, 530327, 530328, 530329, 530330, A61K 3800, A61K 3808, A61K 3812

Patent

active

061002364

ABSTRACT:
The invention provides RGD containing peptides which are cyclized and contain hydrophobic moieties adjacent the carboxy terminus of the RGD sequence. Such peptides have an high affinity for the receptor IIb/IIIa and low affinity for the fibronectin and vitronectin receptors. Such peptides can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis.

REFERENCES:
patent: 4517666 (1985-05-01), Ando
patent: 4547489 (1985-10-01), Goldstein
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4605512 (1986-08-01), Schaller et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4789734 (1988-12-01), Ruoslahti et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4929601 (1990-05-01), Brunetti et al.
patent: 4943562 (1990-07-01), Jolles et al.
patent: 5023233 (1991-06-01), Nutt et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5041380 (1991-08-01), Rouslahti et al.
patent: 5066592 (1991-11-01), Huang et al.
patent: 5612311 (1997-03-01), Pierschbacher et al.
patent: 5643872 (1997-07-01), Ali et al.
patent: 5648330 (1997-07-01), Pierschbacher et al.
patent: 5827821 (1998-10-01), Pierschbacher et al.
Gehlsen et al., J. Cell. Biol. 106:925-930 (1988).
Gehlsen et al., J. Cell. Biol. 105:3097-3104 (1987).
Siebers et al., Eur. J. Biochem. 178:131-140 (1988).
Ruoslahti et al., Cell 44:517-518 (1986).
Ruoslahti et al., Falk Symposium 43:239-244 (1987).
Bodanszky, Principles of Peptide Synthesis 217-222 (1984).
Marx, Science 248:1491-1493 (1990).
Creighton, Proteins 9 (1984).
Dayhoff, Atlas of Protein Sequences and Structure 5:89-99 (1972).
Joubert et al., Biochim. Biophys. Acta. 579:228-233 (1979).
Gan et al., J. Biol. Chem. 263(36):19827-19832 (1988).
Huang et al., J. Biol. Chem. 262(33):16157-16163 (1987).
Pelton et al., Proc. Natl. Acad. Sci. USA 82:236-239 (1985).
Sakakibara et al., BBA 303:198-202 (1973).
Kaiser and Keczy, Science 223:249-255 (1984).
Ohsaku et al., Int. J. Biol. Macromol. 6:234-240 (1984).
Cheresh, Chem. Abstract 104, abstract No. 183980c (1986).
Yamada, Chem. Abstract 107, abstract No. 5066p (1987).
Poole, Chem. Abstract 105, abstract No. 169400c (1986).
Toda et al., J. Cell Biol. 105:3097-3104 (1987).
Singer et al., J. Cell Biol. 104:573-584 (1987).
Lash et al., Dev. Biol. 123:411-420 (1987).
Pierschbacher and Ruoslahti, J. Biol. Chem. 262:17294-17298 (1987).
Haverstick et al., Blood 66:946-952 (1985).
Ruggeri et al., Proc. Natl. Acad. Sci. USA 83:5708-5712 (1986).
Ginsberg et al., J. Biol. Chem. 260:3931-3936 (1985).
Pierschbacher et al., Proc. Natl. Acad. Sci. USA 81:5985-5988 (1984).
Kloczewisk et al., Biochemistry 23:1767-1774 (1984).
Gartner and Bennett, J. Biol. Chem. 260:11891-11894 (1985).
Kleffer and Phillips, Annu. Rev. Cell Biol. 36:329-357 (1990).
Plow et al., Proc. Natl. Acad. Sci. USA 82:8057-8061 (1985).
Pytela et al., Proc. Natl. Acad. Sci. USA 82:5766-5770 (1985).
Pytela et al., Cell 40:191-198 (1985).
Pytela et al., Science 231:1559-1562 (1985).
Gardner et al, Cell 42:439-448 (1985).
Pierschbacher et al., Nature 309:30-33 (1984).
D'Souza et al., J. Biol. Chem. 263:3943-3951 (1988).
Parise et al., J. Biol. Chem. 262:12597-12602 (1987).
Haskei et al., Thromb. Res. 56:687-695 (1988).
Plow et al., Blood 70:110-115 (1987).
Ruoslahti et al., J. Clin. Invest. 87:1-5 (1991).
Ali et al., Peptides Proc. 11th Amer. Peptide Symposium, La Jolla, CA, Marshall & Rivier, eds. (Jul. 9-14, 1989).
Garsky et al., Proc. Natl. Acad. Sci. USA 86:4022-4026 (1989).
Dennis et al., Proc. Natl. Acad. Sci. USA 87:2471-2475 (1989).
Chao et al., Proc. Natl. Acad. Sci. USA 86:8050-8054 (1989).
Shebuski et al., J. Biol. Chem. 264:21550-21556 (1989).
Huang et al., Biochemistry 28:661-666 (1989).
Spatola and Krzysztof, Tetrahedron 44(3):821-833 (1988).
Garo and Spatola, Biochem. Biophys. Res. Commun. 120(3):840-845 (1984).
Edwards and Spatola, Biochem. Biophys. Res. Commun. 136(2):730-736 (1986).
Spatola and Edwards, Biopolymers 25:s229-s244 (1986).
Davies et al., Biochem. Soc. Trans. 18:11326-11328 (1990).
Drickamer et al., J. Biol. Chem. 261:6878-6887 (1986).
Rauvala et al., J. Cell. Biol. 107:2293-2305 (1988).
Maes et al., Fed. Europ. Biochem. Soc. 214:41-45 (1988).
Moos et al., Nature 334:701-703 (1988).
Neurath et al., Mol. Immun. 27:539-549 (1990).
Kirchofer et al., J. Biol. Chem. 265:18525-18530 (1990).
Ratner et al., Nature 313:277-284 (1985).
Bond et al., Biochemistry 28:6110-6113 (1989).
Ohlstein et al., Thromb. Res. 46:576-585 (1987).
Harvey, J. Toxicol.--Toxin Reviews 3:91-137 (1984).
Dufton, CRC Crit. Rev. in Biochem. 14:113-171 (1983).
Olson, Nature 228:438-442 (1970).
Pelton, J. Med. Chem. 29:2370-2375 (1986).
Lebl, Collection Czechosloval Chem. Commun. 49:2680-2688 (1984).
Stanfield, J. Org. Chem. 51:5153-5156 (1986).
Barker, Protein Society 2nd Symposium (1987).
Kopple et al., "Confirmation of Arg-Gly-Asp Containing Heterodetic Cyclic Peptides: Solution and Crystal Studies", J. Am. Chem. Soc., 114:9615-9623, (1992).
Creighton, T., Proteins W. H. Freeman & Co., p. 9, 1984.
Marx, J., Science, 248: 1491-1493, Jun. 1990.
Plow et al. "RGD Sequences & Fibrinogen Binding to Platelets" Blood, vol. 70 (1), pp. 110-115, 1987.
Plow et al. Effect of RGD Peptides on Binding to Platelets P.N.A.S., vol. 82, pp. 8057-8061, 1985.

Affiliated with

Also associated with

Rating

Method and composition for treating thrombosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for treating thrombosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for treating thrombosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1150218