Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-06-08
1991-06-04
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514266, A61K 3152
Patent
active
050214225
ABSTRACT:
It has been discovered that 6-(substituted amino)purine cytokinins, such as kinetin, induce differentiation, and consequently reduce or eliminate the abnormally high rate of proliferation, of hyperproliferating cells associated with hyperproliferative skin diseases, such as psoriasis. Thus, the present invention provides methods and compositions for treating hyperproliferative skin diseases in mammals, particularly such diseases associated with hyperproliferating epidermal cells in humans, by administering to the hyperproliferating cells associated with such a disease, in the skin of a mammal suffering therefrom, a differentiation-inducing effective amount of a 6-(substituted amino)purine cytokinin.
REFERENCES:
Chem. Abstracts, vol. 103:11233z, Yokoyama, JP60-19709, (1985).
Orr and McSwain, The Effects of Kinetin Upon Epithelium and Fibroblasts in Tissue Culture, Cancer 10, 617-624 (1957).
Johnson, et al, N.sup.6 -Substituted Adenines Induce Cell Elongation Irrespective of the Intracellular Cyclic AMP Levels, Exptl. Cell Res. 85, 47-46 (1974).
Hecht et al., Competitive Inhibition of Beef Heart Cyclic AMP Phosphodiesterase by Cytokinins and Related Compounds, Proc. Natl. Acad. Sci. (USA) 71, 4670-4674 (1974).
Mookerjee et al., Effects of Plant Cytokinins on Human Lymphocyte Transformation, J. Reticuloendoth. Soc. 25, 299-314 (1979).
Gordon and Seglen, 6-Substituted Purines: A Novel Class of Inhibitor of Endogenous Protein Degradation in Isolated Rat hepatocytes, Arch. Biochem. Biophys. 217, 282-294 (1982).
Vesely et al, Plant Growth-Promoting Hormones Activate Mammalian Guanylate Cyclase Activity, Endocrinology 116, 1887-1892 (1985).
Bjerring Peter
Bolund Lars
Jensen Peter K. A.
Datlow Philip
Senetek PLC
Shah Mukund J.
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