Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1994-12-09
1996-04-02
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 9463, 424 9464, A61K 9127
Patent
active
055038506
ABSTRACT:
A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intravenous injection of a composition comprising a plurality of microcapsules comprising a plasminogen activator core surrounded by a controlled release semi-permeable layer.
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Johnson Arthur E.
Nguyen Philip D.
O'Rear, III Edgar A.
Patterson Eugene S.
Whitsett Thomas L.
Kishore Gollamudi S.
Research Corporation Technologies Inc.
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