Method and composition for the treatment of cancer

Details Method and composition for the treatment of cancer Method and composition for the treatment of cancer

2005-04-05

2005-04-05

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S023000, C514S033000, C514S034000, C514S256000, C514S262100, C514S264100, C514S274000, C514S275000, C514S454000, C514S455000, C514S922000

Reexamination Certificate

active

06875745

ABSTRACT:
We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a β-lapachone, or a derivative or analog thereof.

REFERENCES:
patent: 5728687 (1998-03-01), Bissery
patent: 5763625 (1998-06-01), Boothman et al.
patent: 5919816 (1999-07-01), Hausheer et al.
patent: 6664288 (2003-12-01), Pardee et al.
patent: WO 9633988 (1996-10-01), None
Coppoc, “Chemotherapy of Neoplastic Diseases”, Chapter 58, Purdue Research Foundation (1996).*
Boothman, et al.,Cancer Res., 49(3):605-612 (1989).
Katz, et al.,Eur. J. Cancer, 26(6);724-727 (1990).
Li, et al.,J. Biol. Chem., 268(30):22463-22468 (1993).
Li, et al.,PNAS,96(23):13369-13374 (1999).
Supplementary European Search Report for EP 00 92 2237, mailing date: May 19, 2004.

Affiliated with

Also associated with

Rating

Method and composition for the treatment of cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for the treatment of cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for the treatment of cancer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3411131