Method and composition for the treatment of cancer

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S023000, C514S033000, C514S034000, C514S256000, C514S262100, C514S264100, C514S274000, C514S275000, C514S454000, C514S455000, C514S922000

Reexamination Certificate

active

06875745

ABSTRACT:
We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a β-lapachone, or a derivative or analog thereof.

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patent: 5919816 (1999-07-01), Hausheer et al.
patent: 6664288 (2003-12-01), Pardee et al.
patent: WO 9633988 (1996-10-01), None
Coppoc, “Chemotherapy of Neoplastic Diseases”, Chapter 58, Purdue Research Foundation (1996).*
Boothman, et al.,Cancer Res., 49(3):605-612 (1989).
Katz, et al.,Eur. J. Cancer, 26(6);724-727 (1990).
Li, et al.,J. Biol. Chem., 268(30):22463-22468 (1993).
Li, et al.,PNAS,96(23):13369-13374 (1999).
Supplementary European Search Report for EP 00 92 2237, mailing date: May 19, 2004.

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