Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1996-09-19
1998-04-07
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3847
Patent
active
057361339
ABSTRACT:
A method and composition are provided for treatment of herpes related disorders. The invention comprises the administration of a low level of neuraminidase protein or a derivative thereof. The method is particularly effective in treating herpes related disorders such as shingles, cold sores, herpes lesions in general and chronic fatigue syndrome.
REFERENCES:
Smiley et al., Journal of Virology 55(3): 857-861 (Sep. 1985).
Tompkins et al., Journal of Immunology 116(2): 489-495 (Feb. 1976).
Hatano et al., Current Eye Research 6(1): 53-57 (1987).
Strauss et al., N. Eng. J. Med. 319(26): 1692-1698 (1988).
Lung et al., Int. J. Cancer 52(1): 34-37 (1992).
Levine et al., Arch. Intern. Med. 152(8): 1611-1616 (1992).
Smiley, L et al., "Binding of Complement Component C3b to Glycoprotein C is Modulated by Sialic Acid on Herpes Simplex Virus Type 1-Infected Cells," Journal of Virology, vol. 55, No. 3, pp. 857-861 (Sep. 1985).
Arora, D.J.S. et al., "In Vivo Enhancement of Human Natural Cell-Mediated Cytotoxicity by Purified Influenza Virus Glycoproteins," Journal of Virology, vol. 52, No. 3, pp. 839-845 (Dec. 1984).
Yarnell, M.M. et al., "Studies of tumor Invasion in Organ Culture-II. Effects of Enzyme Treatment," Europ. J. Cancer, vol. 5, pp. 265-269 (1969).
Tompkins, W.A.F. et al., "Neuramindase Reversal of Resistance to Lysis of Herpes Simplex Virus-Infected Cells by Antibody and Complement," The Journal of Immunology, vol. 116, No. 2, pp. 489-495 (Feb. 1976).
Varghese, J.N. et al., "Structure of the influenza virus glycoprotein antigeuraminidase at 2.9 .ANG. resolution ," Nature, vol. 303, pp. 35-40 (May 5, 1983).
Berwick, L., et al., "Some Chemical Factors in Cellular Adhesion and Stickness," Cancer Research, vol. 22, pp. 982-987 (Sep. 1962).
Hatano, H. et al., "Effect of neuraminidase on Fe and C3b receptors on rabbit corneal cells infrects with herpes simplex virus,"0 Current Eye Research, vol. 6, No. 1, pp. 53-57 (1987).
Boyd, R.F. et al., "Basic Medical Microbiology," Basic Medical Microbiology-Second Edition, p. 527.
Santoli, D. et al., "Mechanism of Activation of Human Natural Killer Cells Against Tumor and Virus-Infected Cells," Immunological Review, vol. 44, pp. 125-163 (1979).
Arnheiter, H. et al., "Host Gene Influence on Interferon Action in Adult Mouse Hepatocytes: Specificity for Influence Virus," Virology, vol. 103, 11-20 (1980).
Miller, J.B., "Treatment of Active Herpes Virus Infections with Influenza Virus Vaccine." Annals of Allergy, vol. 42, pp. 295-305 (May 1979).
Stein-Streilein, J. et al., "In Vivo Treatment of Mice and Hamsters with Antibodies to Asialo GM1 Increases Morbidity and Mortality to Pulmonary Influenza Infection," The Journal of Immunology, vol. 135, No. 4, pp. 1435-1441 (Feb. 15, 1986).
Yasukawa, M. et al., "Autologous Herpes Simplex Virus-Infected Cells are Lysed by Human Natural Killer Cells," The Journal of Immunology, vol. 131, No. 4, pp. 2011-2016 (Oct. 1983).
Ching, C. et al., "Natural Killing of Herpes Simplex Virus Type 1-Infected Target Cells: Normal Human Responses and Influence of Antiviral Antibody," Infection and Immunity, vol. 26, No. 1, pp. 49-56.
St. Geme, Jr., J.W. et al., "Impaired Cellular Resistance to Herpes-Simplex Virus in Wiskott-Aldrich Syndrome," The New England Journal of Medicine, vol. 273, No. 5, pp. 229-234 (1965).
Rawls, W.E., "Herpes Simplex Virus Infectons: Type I and Type 2 Viruses," Laboratory Diagnosis of Viral Infections-Edited by Edwin H. Lennette, Chapter 19, pp. 313-340 (1985).
"The Epstein-Barr Virus", edited by M.A. Epstein et al., published by Springer-VErlag, pp. 298-320 (1979).
Dajer, T., "Herpes Key," Discover, p. 20 (Nov. 1990).
Herring, T. "A Salivary Herpesvirus Interacts with HIV," ASM News, vol. 56, No. 10, pp. 522-523 (1990).
Trinchieri, G. et al., "Anti-Viral Activity Induced by Culturing Lymphocytes with Tumor-Derived or Virus-Transformed Cells," J. Exp. Med., vol. 147, pp. 1299-1313 (1978).
Djeu, J.Y. et al., "Positive Self Regulation of Cytotoxicity in Human Natural Killer Cells by Production of Interferon upon Exposure to Influenza and Herpes Viruses," Journal of Experimental Medicine, vol. 156, pp. 1222-1234 (Oct. 1982).
Nahmias, A.J., et al., "Infection with Herpes-Simplex Viruses 1 and 2," The New England Journal of Medicine, vol. 289, No. 13, pp. 667-674 (Sep. 27, 1973).
McTaggart, S.P. et al., "Fc Receptors Inducted by Herpes Simplex Virus-I, Biologic and Biochemical Properties," The Journal of Immunology, vol. 121, No. 2, pp. 727-730 (Aug. 1978).
Levy, J.A. et al., "Human Herpevirus 6 Inhibits Human Immunodeficiency Virus Type I Replication in Cell Culture," Journal of Clinical Microbiology, vol. 28, pp. 2362-2364 (Oct. 1990).
Lennette, E.T., "Diagnosis of Epstein-Barr Virus Infections," Chapter 16, pp. 257-271.
Haller, O., "Inborn Resistance of Mice to Orthomyxoviruses," Current Topics in Microbiology and Immunology, edited by W. Henle, pp. 25-52 (1981).
Strauss, S.E. et al., "Acyclovir treatment of the chronic fatigue syndrome: Lack of efficacy in a placebo-controlled trial," N. Engl. J. Med., Abstract: 319(26), pp. 1692-1698 (1988) Abstract.
Lung, M.L. et al., "Detection of Distinct Epstein-Barr Virus Genotypes in NPC Biopsies from Southern Chinese and Caucasians," Int. J. Cancer, vol. 52(1), pp. 34-37 (1992) Abstract.
Levine, P.H. et al., "Clinical Epidemiologic and Virologic Studies in Four Clusters of the Chronic Fatigue Syndrome," Arch. Intern. Med., vol. 152(8), pp. 1611-1616, (1992) Abstract.
Welsh, R.M., "Natural Cell-Medicated Immunity During Viral Infections," Natural Resistance to Tumors and Viruses, edited by O. Haller, published by Springer-Verlag, pp. 83-106 (1981).
Kline Ellis L.
McAlhaney Walter W.
Molecular Rx, Inc.
Witz Jean C.
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