Method and composition for the preparation of controlled long-ac

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 22, 424362, A61K 902, A61K 920, A61K 922, A61K 4700

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active

042593140

ABSTRACT:
A method and composition for the preparation of controlled long-acting pharmaceuticals using a dry carrier or base material comprising an effective amount of hydroxypropyl methylcellulose and hydroxypropyl cellulose suitable for use with both hygroscopic and non-hygroscopic materials. The controlled long-acting products of the invention are suitable for use in the form of lozenges, buccal tablets, oral tablets or suppositories.

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patent: 4179497 (1979-12-01), Cohen et al.
Forest Laboratories, Inc., Lowey H. Tablets Based on Hydroxy-Propyl Methyl Cellulose Treated by Adjusting Moisture Content to 85% Then Drying to 5% for Continuous Release of Pharmaceutical DT2718260 (11-17-77) FR2358895, J52145514.
Lowey, H. Slow Release Compns. Based on Hydroxypropylmethyl Cellulose, NL7308859, DT2332484, FR290409, GB1430684, CA1018456, J4905419.
Hercules, Inc., "Fact Sheet On Klucel", 2 pp. Dec. 4, 1972.
Hercules, Inc., "Klucel Hydroxypropyl Cellulose", 32 pp. (1971).
Klug, J. Polymer. Sci., Part C, No. 36:491-508 (1971) "Some Properties of Water-Soluble Hydroxyalkyl Celluloses and Their Derivatives".

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