Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1989-02-21
1992-08-25
Kepplinger, Esther L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 75, 435 792, 436811, G01N 33543
Patent
active
051418762
ABSTRACT:
The invention refers to a method as well as a composition for the quantitative determination of kidney damages by the application of polyclonal and monoclonal antibodies against villin and/or fimbrin appearing in the urine as soon as damages of the kidney, for example reactions of rejection in case of a transplanted kidney or tubular inflammations, are occurring.
REFERENCES:
patent: 4465776 (1984-08-01), Cidlowski et al.
patent: 4731326 (1988-03-01), Thompson et al.
Rodman, J. S. et al., "Cytoskeletal Proteins of the Rat Kidney Proximal Tubule Brush Border", European Journal of Cell Biology (1986), vol. 42, pp. 319-327.
Bretscher, A. et al., "Villin Associates with Specific Microfilamentous Structures as seen by Immunofluorescence Microscopy on Tissue Sections and Cells Microinjected with Villin", Experimental Cell Research (1981), col. 135, pp. 213-219.
Bretscher, A. et al., "Fimbrin, a New Microfilament-Associated Protein Present in Microvilli and Other Cell Surfaces", Journal of Cell Biology (1980), vol. 86, pp. 335-340.
Bretscher, A. et al., "Villin is a Major Protein of the Microvillus Cytoskeletono Which Binds Both G and F Actin in a Calcium-Dependent Manner", Cell (1980), vol. 20, pp. 839-847.
Drenckhahn, D. et al., "Evidence for the Association of Villin with Core Filaments and Rootlets of Intestinal Epithelial Microvilli", Cell and Tissue Research (1983), vol. 228, pp. 409-414.
ICN Biomedicals Inc. Reference Catalog 1987, pp. 1B-1, 1B-2, 1B-49.
Bretscher et al., Proc. Natl. Acad. Sci. USA 76(1979), pp. 2321-2325.
Kohler and Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature 256: 495-497 (Aug. 7, 1975).
Bidwell Carol E.
Kepplinger Esther L.
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