Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1979-08-23
1981-02-24
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424177, 424271, A61K 4900
Patent
active
042527848
ABSTRACT:
The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, and novel test methods employing such materials.
The new PPL preparations comprise homogeneous, high purity, maximally coupled, .alpha.-diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: ##STR1## wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephalosporins or other .beta.-lactam antibiotics; and
REFERENCES:
Levine et al., J. of Clin. Invt., vol. 47, Mar. 1968.
Levine et al., Int. Arch. of Allergy & Applied Immunol, vol. 35, 1969, pp. 445-455.
Levine et al., The J. of Allergy, vol. 43, Apr. 1969, pp. 231-244.
Levine, Sci. Writers Seminar, Allergic disease Res. Drug Allergy, Remarks, Jan. 26, 1971, 14 pp. (DHEW pub. 73-202).
Levine, J. of Med. & Pharm. Chem., vol. 5, 1962, pp. 1025-1034.
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