Method and composition for systemic treatment of tissue injury

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514 21, A61K 3736, A61K 3156, A61K 3316

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054079136

ABSTRACT:
This is a method for enhancing systemic tissue repair in patients with burns, trauma and peptic ulcers, as well as patients about to undergo, is undergoing or just having undergone surgery. The method comprises systemically administering to such individuals a therapeutic composition comprising IGF and IGFBP. The preferred form is IGF-I/IGFBP-3.

REFERENCES:
patent: 4783524 (1988-11-01), Larsen
patent: 5187151 (1993-02-01), Clark
Baxter, Comp. Biochem. Physiol., vol. 91B(2), 229-235, 1988.
Baxter in Modern Concepts of Insulin-Like Growth Factors, edited by Spencer, Elsenior Science Publishing Co., Inc., 1991, pp. 371-380.
Blum et al., Endocrinology, 125(2), 766-772, 1989.
Gartner, M. H., et al., "Insulin-Like Growth Factors I and II Expression in the Healing Wound", J. Surg. Res. (1992) 52:389-394.
Skottner, A., et al., "Tissue Repair and IGF-I", Acta Pediatr. Scand. (Suppl.) (1988) 347:110-112.
Coates, C. L., et al., "Somatomedin Activity in Plasma From Burned Patients With Observations on Plasma Cortisol", Burns (1981) 7:425-433.
Cunningham, J. J., et al., "Plasma Somatomedin-C as an Index of Nutritional Status Following Burn Trauma and Chronic Malnutrition", Proceedings of the American Burn Association, 18 Annual Meeting (9-12 Apr. 1986, Chicago, IL), vol. 18, p. 128.
Moller, S., et al., "Insulin-Like Growth Factor 1 (IFG-1) in Burn Patients", Burns (1991) 17:279-281.
Strock, L. L., et al., "The Effect of Insulin-Like Growth Factor I on Postburn Hypermetabolism", Surgery (1990) 108:161-164.
Sara, V. R., et al., "The Influence of Early Nutrition on Growth and the Circulating Levels of Immunoreactive Somatomedin A", J. Develop. Physiology (1979) 1:343-350.
Hansson, H. A., et al., "Evidence Indicating Trophic Importance of IGF-I in Regenerating Peripheral Nerves", Acta Physiol. Scand. (1986) 126:609-614.
D'Ercole, A. J., "Somatomedins/Insulin-Like Growth Factors and Fetal Growth", J. Develop. Physiology (1987) 9:481-495.
Brewer, M. T., et al., "Cloning, Characterization, and Expression of a Human Insulin-Like Growth Factor Binding Protein", Biochem. Biophys. Res. Comm. (1988) 152(3):1289-1297.
Hintz, R. L., et al., "A Sensitive Radioimmunoassay for Somatomedin-C/Insulin-Like Growth-Factor I Based on Synthetic Insulin-Like Growth Factor 57-70", Horm. Metabol. Res. (1988) 20:344-347.
Baxter, R. C., "The Insulin-Like Growth Factors and Their Binding Proteins", Comp. Biochem. Physiol. (1988) 91B:229-235.
Sjoberg, J., et al., "Insulin-Like Growth Factor (IGF-1) as a Stimulator of Regeneration in the Freeze-Injured Rat Sciatic Nerve", Brain Research (1989) 485:102-108.
Daughaday, W. H., et al., "Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations", Endocrine Reviews (1989) 10(1):68-91.
Binkert, C., et al., "Cloning, Sequence Analysis and Expression of a cDNA Encoding a Novel Insulin-Like Growth Factor Binding Protein (IGFBP-2)", The EMBO Journal (1989) 8(9):2497-2502.
Busby, W. H., et al., "Purification of a 31,000-Dalton Insulin-Like Growth Factor Binding Protein from Human Amniotic Fluid", J. Biol. Chem. (1988) 263(28):14203-14210.
Elgin, R. G., et al., "An Insulin-Like Growth Factor (IGF) Binding Protein Enhances The Biologic Response to IGF-I", Proc. Natl. Acad. Sci. (1987) 84:3254-3258.
Blum, W. F., et al., "Plasma IGFBP-3 Levels as Clinical Indicators", in Modern Concepts in Insulin-Like Growth Factors, E. M. Spencer, editor, (published by Elsevier, N.Y., 1991) pp. 381-393.
Wood, W. I., et al., "Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein", Mol. Endocrin. (1988) 2:1176-1185.
Spratt, S. K., et al., "Cloning and Expression of Human Insulin-Like Growth Factor Binding Protein 3", Growth Factors (1990) 3:63-72.
Martin, J. L., et al., "Insulin-Like Growth Factor-Binding Protein From Human Plasma", J. Biol. Chem. (1986) 261(19):8754-60.
Sommer, A., et al., "Molecular Genetics and Actions of Recombinant Insulin-Like Growth Factor Binding Protein-3", in Modern Concepts in Insulin-Like Growth Factors, E. M. Spencer, editor, (published by Elsevier, N.Y., 1991) pp. 715-728.
Shimasaki, S., et al., "Identification and Molecular Characterization of Insulin-Like Growth Factor Binding Proteins", Prog. Growth Factor Res. (1991) 3:243-266.
Spencer, E. M., et al., "Somatomedins: Do They Play a Pivotal Role in Wound Healing?", in Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications (1988), pp. 103-116.
Jennische, E., et al., "Dynamic Changes in Insulin-Like Growth Factor I Immunoreactivity Correlate to Repair Events in Rat Ear After Freeze-Thaw Injury", Epx. Mol. Pathol. (1987) 47:193-201.

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