Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1987-01-27
1990-01-30
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514277, 514419, A61K 3140, A61K 3170, A61K 31435
Patent
active
048973807
ABSTRACT:
A composition for treating physiological disorders responsive to treatment with the neurotransmitter serotonin includes L-tryptophan, fructose, niacinamide, pyridoxine, calcium ascorbate, copper gluconate and magnesium oxide. Each ingredient either promotes the transport of L-tryptophan from the blood plasma across the blood-brain barrier into the brain, or promotes the synthesis of serotonin from L-tryptophan.
REFERENCES:
"A New Activator Protein That Activates Tryptophan 5-Monooxygenase and Tyrosine 3-Monooxygenase in the Presence of Ca.sup.2+ -, Calmodulin-Dependent Protein Kinase", Takashi Yamauchi et al., The Journal of Biological Chemistry, vol. 256, No. 11, pp. 5404-5409, Jun. 10, 1981.
"The Respective Roles of Tryptophan Uptake and Tryptophan Hydroxylase in the Regulation of Serotonin Synthesis in the Central Nervous System", J. Physiol., Paris, 1981, vol. 77, pp. 269-279, Symposium the Serotoninergic Neuron CNRS, Marseille, Jul. 9-14, 1980, M. Hamon et al.
"Ca.sup.2+ -Guanine Nucleotide Interactions in Brain Membranes. I. Modulation of Central 5-Hydroxytryptamine Receptors in the Rat", M. Mallat et al., Journal of Neurochemistry, 1982, pp. 151-161.
"Serotonin and Lysergic Acid Diethylamide Binding in Rat Brain Membranes: Relationship to Postsynaptic Serotonin Receptors", James P. Bennett, Jr. et al., Molecular Pharmacology, vol. 12, pp. 373-389, 1976.
Durst Lawrence
Pollack Robert L.
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