Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-08-01
1987-09-08
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514808, 514159, 424450, A61K 31245, A61K 942, A61K 3730, A61K 3724
Patent
active
046924337
ABSTRACT:
Method for regulating serum calcium levels in mammals by orally administering a composition which includes a polypeptide hormone such as parathyroid hormone (PTH) or calcitonin. The polypeptide hormone is protected from destruction in the digestive tract by encapsulation in liposomes. The liposome preferably includes a cationic amphiphilic agent so that the surface of the liposome has a net positive charge. Agents for enhancing the action of the liposome encapsulated hormones are also disclosed.
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patent: 4342826 (1982-08-01), Cole
patent: 4459295 (1984-07-01), Higuchi et al.
Taylor et al, cited in Chem. Abstracts, vol. 93:184604z.
Epand et al., cited in Chem. Abstracts, vol. 99:152321n.
Potts et al, cited in Chem. Abstracts, vol. 72:51369w.
Hemker et al, The Lancet, 1-12-80, pp. 70-71.
Deftos Leonard J.
Hostetler Karl Y.
Brown Johnnie R.
Stone Jacqueline M.
The Regents of the University of California
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