Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1980-08-08
1981-12-22
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424324, A61K 31165
Patent
active
043070736
ABSTRACT:
A method and composition for reducing the toxicity of acetaminophen to a warm blooded animal. The method comprises administering to the animal a sufficient dose of propylene glycol. The sufficient dose is an amount of from about 0.3 to about 12 grams per kilogram of body weight of the animal. The composition comprises a mixture of acetaminophen and propylene glycol preferably in a weight ratio of propylene glycol to acetaminophen of from about 0.3:1 to about 4000:1.
REFERENCES:
patent: 3173835 (1965-03-01), Weiner et al.
patent: 3317377 (1967-05-01), Hill et al.
patent: 4017614 (1977-04-01), Wild
patent: 4181719 (1980-01-01), Margetts et al.
APhA Handbook of Nonprescription Drugs, 5th ed., (1977) pp. 120-133, Internal Analgesic Products (Acetaminophen Syrup Elixir Suspension Drops & Liquid).
U.S. Disp. 25th ed., (1955) Pt. I, pp. 1134-1135, "Propylene Glycol, USP".
C.A. 80#6793j, (1974) 78#53489h, (1973) 81#33115s, (1974) 89#190746a, (1978) 89#41137f #41138g #41139h, (1978) 80#67049t, (1974).
Dunn Michael L.
Rose Shep K.
The Research Foundation of State University of New York
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