Method and composition for reducing serum cholesterol

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424468, 514824, 514960, A61K 3578, A61K 922

Patent

active

048246727

ABSTRACT:
An orally administrable composition and method for reducing serum cholesterol levels are disclosed. A pharmaceutical composition comprising a gel-forming fiber such as, for example, guar gum, pysllium seed, pectin, glucomannon, oat and barley and a mineral salt such as for example, calcium carbonate, magnesium carbonate and potassium carbonate is administered to humans to reduce serum cholesterol levels.

REFERENCES:
patent: 3952096 (1976-04-01), Godfrey et al.
patent: 4377601 (1983-03-01), Dreese et al.
patent: 4764374 (1988-08-01), Grimberg
Kannel, W. B., Thom, T. J., "Declining Cardiovascular Mortality", Circulation, 70:331-336 (1984).
National Institutes of Health Consensus Development Conference on Lowering Blood Cholesterol to Prevent Heart Disease, JAMA: 253, No. 14, 2980-2086 (1985).
Dawber, T. R., The Framingham Study, Cambridge, MA., Harvard University Press, pp. 1-13 and 121-141, (1980).
Thelle, D. S. et al., "The Tromso Heart Study: Methods and Main Results of the Cross-Sectional Study", Acta. Med. Scand., 200:107-118 (1976).
Ross, R., Glomset, J., "The Pathogenesis of Atherosclerosis", N. Engl. J. Med., 295:369-377, (1976).
Henriksen, T. Mahoney, E. M. Steinberg, D., "Interactions of Plasma Lipoproteins With Endothelial Cells", Ann. N.Y. Acad. Sci., 401:102-116 (1982).
U.S. Department of Health and Human Services: Cardiovascular Primer for the Workplace, NIH Publication No. 81-2210, pp. 1-88, esp. p. 75 (Jan. 1981).
Lipid Research Clinics Program: The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in Incidence of Coronary Heart Disease, and II. The Relationship of Reduction in Incidence of Coronary Heart Disease to Cholesterol Lowering, JAMA, 251: 351-374 (1984).
Superko, H. R., "Decreasing Blood Cholesterol Levels With a Dietary Additive: An Additional Approach to Diet and Drugs", Cardiovascular Reviews & Reports, 6: No. 11, 1253-1265 (Nov. 1985).
Khan, A. R. et al., "Effect of Guar Gum on Blood Lipds", The American Journal of Clinical Nutrition, 34:2446-2449 (Nov. 1981).
Mokady, S., "Effect of Dietary Pectin and Algin on Blood Cholesterol Level in Growing Rats Fed a Cholesterol-Free Diet", Nutr. Metabol., 15:290-294 (1973).
Kay, R. M. et al., "Effect of Citrus Pectin on Blood Lipids and Fecal Seroid Excretion in Man", Am. J. Clin. Nutr., 30:171-175 (1977).
Johnson et al., "Effect on Gel-Forming Gums of the Intestinal Unstirred Layer and Sugar Transport in Vitro", Gut, 22:398-403 (1981).
Isaksson, G. et al., "In Vitro Inhibition of Pancreatic Enzyme Activities by Dietary Fiber", Digestion, 24:54-59 (1982).
Jenkins, D. J. et al., "Effect of Pectin, Guar Gum, and Wheat Fibre on Serum-Cholesterol", The Lancet, 1116-1117, (May 17, 1975).
Jenkins, D. J. A., "Dietary Fiber and Other Antinutrients: Metabolic Effects and Therapeutic Implications", Nutritional Pharmacology, p. 121, (1981).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and composition for reducing serum cholesterol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for reducing serum cholesterol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for reducing serum cholesterol will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1194894

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.