Method and composition for protein immobilization

Details Method and composition for protein immobilization Method and composition for protein immobilization

1983-06-23

1986-02-25

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

422 57, 424 36, 436531, 436810, 436823, G01N 33544, G01N 33545, G01N 148, A61K 938

Patent

active

045729018

ABSTRACT:
Compositions, articles of manufacture, and methods are provided for enhanced binding of compounds to a surface. The compositions find particular use in coating wells, slides, other surfaces, where ligands or receptors are to be bound and detrimental non-specific binding may be encountered. Particularly, proteins are modified by alkylation to produce a product which strongly adheres to a surface, allows ligands and receptors to be firmly attached by means of the alkylated protein to a surface under mild non-denaturing conditions and permits procedures to minimize non-specific binding of proteins without significant loss of the materials of interest.

REFERENCES:
patent: 4234563 (1980-11-01), Rippe
patent: 4341761 (1982-07-01), Ganfield et al.
patent: 4456553 (1984-06-01), Oshida et al.
American Hosp. Supply Corp., Chem. Abstracts, 92 (1980) #179002b.
Sato et al., Chem. Abstracts, 100 (1984) #154962k.
Asahi Chem. Ind. Co. Ltd., Chem. Abstracts, 94 (1981) #36396p.

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