Method and composition for preventing surgical adhesions and tis

Details Method and composition for preventing surgical adhesions and tis Method and composition for preventing surgical adhesions and tis

1999-02-10

2000-07-18

Milano, Michael J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

524805, 424 7806, A61F 202, C08J 216, A61K 31785

Patent

active

060909978

ABSTRACT:
An improved method for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The polymeric material is (1) a substantially water-soluble polymer having at least one C.sub.n F.sub.2n+1 substituent wherein n.gtoreq.4, having a molecular weight of less than about 60,000; (2) a pharmaceutically acceptable salt or complex thereof; or (3) mixtures thereof. The concentration of the aqueous solution of the polymeric material is in the range of from about 0.1% to about 5.0% by weight, the molecular weight and concentration having values such that the aqueous solution is capable of providing wet coatings on the tissue.

REFERENCES:
patent: 5256731 (1993-10-01), Huth et al.
patent: 5350573 (1994-09-01), Goldberg et al.
patent: 5941909 (1999-08-01), Purkait
patent: 5980625 (1999-11-01), Sawamura et al.

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