Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1993-12-20
1995-04-18
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 25, 435189, 424 71, 424 9, 436 63, 436 64, 436813, 514410, C12Q 104, C12Q 126, G01N 3348, A61K 3140
Patent
active
054078083
ABSTRACT:
Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting the cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating the cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in the cells thereby causing a buildup of protoporphyrin IX in the cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.
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Camadro et al. "Kinetic Properties of Membrane Bound Human Liver Mirochondrial Protoprophyrinogen Oxidase" Arch Biochem Biophys 242(1):206-212 1985.
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Halling Blaik P.
Yuhas Debra A.
Craig Norman L.
FMC Corporation
Gromet Nancy J.
Kennedy Robert M.
Sheffer Abner
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