Method and composition for optimizing left ventricular videointe

Details Method and composition for optimizing left ventricular videointe Method and composition for optimizing left ventricular videointe

1994-09-06

1996-11-26

Dees, Jose G.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

A61K 4900

Patent

active

055782914

ABSTRACT:
This invention provides a new ultrasound contrast agent which is safe and can reach the left side of the heart in adequate amounts to determine blood flow to the muscle of the heart. The contrast agent comprises a simple sonicated mixture of a protein the body normally makes (albumin) combined with a naturally occurring sugar (dextrose). This mixture upon sonication contains small bubbles (microbubbles) and can be used following an intravenous injection to study blood flow to the muscle of the heart (myocardium) without the need of invasive catheters or radiation. In another embodiment, there is provided an inexpensive test to study blood flow in the heart using echocardiography, thus avoiding the more expensive nuclear procedures that are presently employed to determine blood flow in the heart muscle, and eliminating the risk of radiation.

REFERENCES:
CA102(12):100841t, "Ultrasound Contrast Agent", Rasor et al.. DE 3,324,754 Jan. 17, 1985.
Medline Abstract #90376405, "On the applization of ultrasonic contrast agents for blood flowmetry & assessment of cardiac perfusion," Bleeker et al, J Ultrasound Med, Aug. 1990 p. 461.

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