Method and composition for modulation of systemic...

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from snake

Reexamination Certificate

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Reexamination Certificate

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07985428

ABSTRACT:
The present invention relates to pharmaceutical composition comprising animal venom and using same in a method for the treatment of Systemic Inflammatory Response Syndrome (SIRS) and related pathologies.

REFERENCES:
patent: 4341762 (1982-07-01), Haast
patent: 6555109 (2003-04-01), Shulov et al.
patent: 2002/0031509 (2002-03-01), Ortenheim et al.
patent: 2003/0175261 (2003-09-01), Weickmann
patent: 01/47535 (2001-07-01), None
Cid et al., “Tissue Production of IL-1beta, TNFalfa and IL-6 correlates with the intensity of the systemic inflammatory response (SIR) and with corticosteroid requirements in giant-cell arthritis (GCA).”FASEB Journal, v. 18:4-5, Abst. 771.3 (2004).
K. Stocker, “Use of Snake Venom Proteins in Medicine.”Swiss Medical Weekly Review, v. 129, pp. 205-216 (1999).
Rajendra et al., “Toxins in anti-nociception and anti-inflammation.”Toxicon, v. 44, pp. 1-17 (2004).
Clissa et al., “The effect of jararhagin, a metalloproteinase fromBothrops jararacavenom, on pro-inflammatory cytokines released by murine peritoneal adherent cells.”Toxicon, v. 39, pp. 1567-1573 (2001).

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