Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1998-05-15
1999-11-09
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 29, 514639, 514638, 514600, 514601, 514395, 514310, 514255, C12Q 100
Patent
active
059811684
ABSTRACT:
Methods and compositions, useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's Disease (AD). These methods involve administering to a subject a pharmaceutical composition including one or more agents which modulate APP catabolism and amyloid deposition. Accordingly, the methods and compositions are useful for inhibiting amyloidosis in disorders in which amyloid deposition occurs. The methods are based, at least in part, on modulating catabolism of APP in APP-containing cells through the use of a mobile ionophore, such as carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone, which does not substantially alter the viability of those cells.
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Connop Bruce P.
Reiner Peter B.
Leary Louise N.
The University of British Columbia
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