Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-12
2000-11-21
Borin, Michael
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514824, 530328, 530329, A61K 3808, A61K 3804, C07K 706
Patent
active
061503320
ABSTRACT:
.alpha..sub.1 -antitrypsin and peptide fragments and derivatives thereof are used to upregulate low density lipoprotein (LDL) cholesterol receptor levels in the liver, and this results in a decrease in circulating LDL cholesterol levels in the patient's circulatory system. In particular, the fragments are:
REFERENCES:
patent: 5792749 (1998-08-01), Wright
Ngo, J.T. et al. In: The Protein Folding Problem and tertiiary structure prediction. Eds. K. Merz, S. LeGrand. Birkhauser, Boston, p. 492-495, 1994.
Database CaPlus, DN 126:130776. Sugano,M. et al. Hissu Aminosan Kenkyu linkai, 144, 16-19, Jan. 1995.
Kroon et al. Netherlands J. of Medicine, 51, 16-27, Jan. 1997.
Grove et al. J.Lipid Res., 32, 1889-1897, 1991.
Liu et al. Cell Growth and Differentiation, 4, 611-616, 1994.
Janciauskiene S.
Wright H. Tonie
Borin Michael
Virginia Commonwealth University
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