Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-09-05
2006-09-05
Nickol, Gary (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387700, C530S388100, C530S300000
Reexamination Certificate
active
07101975
ABSTRACT:
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.
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Brooks, P.C.,MMP-9 binds to a ligand induced cryptic site with β1 integrin: role in angiogenesis and tumor growth, In Vitro Cellular & Developmental Biology Animal, (Mar. 2000) vol. 36, No. 3, Part 2, pp. 29.A. Print. Meeting Info.: Meeting of the Society for In Vitro Biology World Congress on In Vitro Biology, San Diego, CA, USA, Jun. 10-15, 2000.
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Brooks Peter C.
Rodriguez Dorothy
Hogan & Hartson LLP
Nickol Gary
University of Southern California
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