Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-27
2000-03-07
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5147721, 514723, 514822, 514885, 514950, 514975, A01N 4390, A61K 3152
Patent
active
060340886
ABSTRACT:
A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
REFERENCES:
patent: 2674619 (1954-04-01), Lundsted
patent: 2677700 (1954-05-01), Jackson et al.
patent: 2979528 (1961-04-01), Lundsted
patent: 3036118 (1962-05-01), Jackson et al.
patent: 3535307 (1970-10-01), Moss et al.
patent: 3590125 (1971-06-01), Hymes
patent: 3639575 (1972-02-01), Schmolka
patent: 3740421 (1973-06-01), Schmolka
patent: 3829506 (1974-08-01), Schmolka
patent: 3867521 (1975-02-01), Miskel et al.
patent: 3867533 (1975-02-01), Schmolka
patent: 4076799 (1978-02-01), Willer et al.
patent: 4188373 (1980-02-01), Krezanoski
patent: 4439196 (1984-03-01), Higuchi
patent: 4465663 (1984-08-01), Schmolka
patent: 4474751 (1984-10-01), Haslam et al.
patent: 4474752 (1984-10-01), Haslam et al.
patent: 4474753 (1984-10-01), Haslam et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4495168 (1985-01-01), Schmolka
patent: 4495169 (1985-01-01), Schmolka
patent: 4511563 (1985-04-01), Schmolka
patent: 4540407 (1985-09-01), Dunn
patent: 4767619 (1988-08-01), Murray
patent: 4810503 (1989-03-01), Carson et al.
patent: 4861760 (1989-08-01), Mazuel et al.
patent: 4879109 (1989-11-01), Hunter
patent: 4883660 (1989-11-01), Blackman et al.
patent: 4889722 (1989-12-01), Sheffield et al.
patent: 5068225 (1991-11-01), Pennel et al.
patent: 5071644 (1991-12-01), Viegas et al.
patent: 5077033 (1991-12-01), Viegas et al.
patent: 5124151 (1992-06-01), Viegas et al.
patent: 5126141 (1992-06-01), Henry
patent: 5135751 (1992-08-01), Henry
patent: 5143731 (1992-09-01), Viegas et al.
patent: 5366735 (1994-11-01), Henry
Harold Ellis, "The Cause and Prevention of Postoperative Intraperitoneal Adhesions", Surgery, Gynecology & Obstertics, vol. 133, p. 497 (Sep. 1971).
Cary B. Linsky et al., "Adhesion Reduction in the Rabbit Uterine Horn Model Using an Absorbable Barrier, TC-7",The Journal of Reproductive Medicine, vol. 32, p. 17-20 (1987).
Irving R. Schmolka, "ArtificialSkin I Preparation and Properties of Pluronic .RTM. F-127 Gels for Treatment of Burns", Journal of Biomedical Material Research, vol. 6, p. 571 (1972).
Clark M. Smith II,et al., "Pluronic F-68 Reduces the Endothelial Adherence and Improves the Rheology of Liganded Sickle Erythrocytes", Blood, vol. 69, No. 6, pp. 1631-1636 (1987).
Robert Hunter et al., "The Adjuvant Activity of Nonionic Block Polymers Surfactants", Journal of Immunology, vol. 127, pp. 1244-1250 (1981).
Menzies and Ellis, "Intestinal Obstruction from Adhesions--How Big is the Problem?" Annals of the Royal College of Surgeons of England, vol. 72, pp. 60-63 (1990).
Holtz, Baker and Tsai, Fertility and Sterility, vol. 33, No. 6, pp. 660-662 (1980).
Holtz, Baker, Fertility and Sterility, vol. 34, No. 4, pp. 394-395 (1980).
diZerega, "Reduction of Post-operative Pelvic Adhesions with Intraperitoneal 32% Dextran 70: A Prospective. Randomized Clinical Trial", Fertility and Sterility, vol. 40, 5, pp. 612-619 (1983).
Borten, Seibert, and Taymor, "Recurrent Anaphylactic Reaction to Intraperitoneal Dextran 75 Used for Prevention of Postsurgical Adhesions", Obstetrics and Gynecology, vol. 61, No. 6, pp. 755-757 (1983).
Edlich et al., Journal of Surgical Research, vol. 14, No. 4, pp. 277-284 (1973).
Steinleitner et al., Poloxamer 407 as an Intraperitoneal Barrier Material for the Prevention of Post-Surgical Adhesion Formation and Reformation in Rodent Models for Reproductive Surgery, Obstetrics and Gynecology, vol. 1, pp. 48-52 (1991).
Steinleitner, "New Modalities Under Development for Adhesion Prevention; Immunomodulatory Agents and Poloxamer Barrier Materials", Gynecologic Surgery and Adhesion Prevention, pp. 235-251 (1993).
Shimanuki, et al., J. Biomed Materials Research, vol. 21, pp. 173-185 (1987).
Flore Stephen G.
Reeve Lorraine E.
Krass Frederick
MDV Technologies, Inc.
LandOfFree
Method and composition for inhibiting post-surgical adhesions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and composition for inhibiting post-surgical adhesions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for inhibiting post-surgical adhesions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-363378