Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Selenium or compound thereof
Patent
1988-09-27
1991-01-29
Rollins, John W.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Selenium or compound thereof
A61K 3304
Patent
active
049885170
ABSTRACT:
It is shown that benzylselenocyanate in the diet significantly inhibits the incidence (percentage of animals with tumors) and multiplicity (number of tumors per animal) of adenocarcinomas in the colon and multiplicity of adenocarcinomas in the small intestine compared to those fed a control diet. Selenium-dependant glutathione peroxidase activity is significantly increased in kidneys and colon and small intestinal mucosae of animals fed a benzylselenocyanate diet compared to animals fed control diets. BSC in the diet is a superior inhibitor to both its sulfur analog BTC and the inorganic selenium (sodium selenite) during the initiation phase of carcinogenesis.
REFERENCES:
Bandaru S. Reddy et al., "Effect of Dietary Excess of Inorganic Selenium during Initiation and Post-Initiation Phases of Colon Carcinogenesis in F344 Rats", Cancer Research, 48, pp. 1777-1780, Apr. 1, 1988.
Jaya Nayini et al., "Chemoprevention of Experimental Mammary Carcinogenesis by the Synthetic Organoselenium Compound, Benzylselenocyanate, in Rats", Carcinogenesis, vol. 10, No. 3, pp. 509-512, 1989.
Shigeyuki Sugie et al., "Inhibition by Dietary Benzylselenocyanate of Hepatocarcinogenesis Induced by Azoxymethane in Fischer 344 Rats", Jpn. J. Cancer Res., 80, pp. 952-957, Oct. 1989.
Bandaru S. Reddy et al., "Inhibitory Effect of Dietary p-Methoxybenzeneselenol on Azoxymethane-Induced Colon and Kidney Carcinogenesis in Female F344 Rats", J. Natl. Cancer Inst., vol. 74, No. 6, pp. 1325-1328, Jun. 1985.
Bandaru S. Reddy et al., "Chemoprevention of Colon Carcinogenesis by Dietary Organoselenium, Benzylselenocyanate, in F344 Rats", Cancer Research, 47, pp. 5901-5904, Nov. 15, 1987.
El-Bayoumy Karam
Reddy Bandaru S.
American Health Foundation
Rollins John W.
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