Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2007-05-01
2007-05-01
Wax, Robert A. (Department: 1656)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S012000, C435S227000
Reexamination Certificate
active
10621833
ABSTRACT:
A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.
REFERENCES:
patent: 4837380 (1989-06-01), Deftos et al.
patent: 5411884 (1995-05-01), Hellstrom et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5750496 (1998-05-01), Forney et al.
patent: 6126938 (2000-10-01), Guy et al.
patent: 6248330 (2001-06-01), Labigne et al.
patent: 6426086 (2002-07-01), Papahadjopoulos et al.
patent: 2003/0108966 (2003-06-01), Mather
patent: WO 95/22987 (1995-08-01), None
patent: WO95/31480 (1995-11-01), None
patent: WO 98/37207 (1998-08-01), None
patent: WO 01/00245 (2001-01-01), None
Int'l. Search Report from Int'l. Appln. No. PCT/CA03/01061; Int'l. Filing Date: Jul. 16, 2003.
Bagshawe, K.D., et al., “A cytotoxic agent can be generated selectively at cancer sites,”Br. J. Cancer58 pp. 700-703 (1988).
Herron, J.N., et al., “Antibodies and targeting moieties: affinity measurements, conjugation chemistry and applications in immunoliposomes,”J. Controlled Release28:1/3 pp. 155-166 (1994).
Raghunand, N., et al., “Enhancement of chemotherapy by manipulation of tumour pH,”B. J. Cancer80:7 pp. 1005-1011 (1999).
Shi, G., et al., “Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations,”J. Controlled Release80:1-3 pp. 309-319 (2002).
Wampler, G.L., et al., “Antitumor activity of acetohydroxamic acid,”Proceedings of AACR and ASCO, Abstract18 p. 214 (1977).
Zimber, A., et al., “Effect of Urease Injections on Ehrlich Ascites Tumor Growth in Mice,”Proceedings of the Society for Experimental Biology and Medicine139:1 143-149 (1972).
Chao Heman
Dickstein Jodi
Docherty John
McElroy Jerry
Segal Don
Dehlinger Peter J.
Helix Biopharma Corporation
Perkins Coie LLP
Wax Robert A.
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