Method and composition for hyperthermally treating cells

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

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Reexamination Certificate

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07101571

ABSTRACT:
A method for the hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturization. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 50° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

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patent: 5094854 (1992-03-01), Ogawa et al.
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patent: 5935942 (1999-08-01), Zeimer
patent: 5976502 (1999-11-01), Khoobehi et al.
patent: 6248727 (2001-06-01), Zeimer

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