Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1991-05-28
1994-04-19
Nucker, Christine M.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436500, 436518, 436524, 436528, 436529, 436804, 436828, G01N 33566, G01N 3353, G01N 33543, G01N 33551
Patent
active
053044983
ABSTRACT:
A method for determining the amount of free ligand in a test ample where the ligand is also present bound to one or more endogenous receptors, comprising combining the test sample, ligand receptor and unlabelled, differential binding ligand analogue, incubating to permit the free ligand and unlabelled, differential binding ligand analogue to compete for the ligand receptor separating the ligand analogue, determining the amount of ligand receptor bound to the ligand or to the ligand analogue, and correlating the amount of bound ligand receptor to the amount of free ligand present in the test sample.
REFERENCES:
patent: 4200436 (1980-04-01), Mochida et al.
patent: 4292296 (1981-09-01), Parsons, Jr.
patent: 4366143 (1982-12-01), Midgley et al.
patent: 4410633 (1983-10-01), Hertl et al.
patent: 4426453 (1984-01-01), Cree et al.
patent: 4430318 (1984-02-01), Langone
patent: 4481298 (1984-11-01), Cone, Jr. et al.
patent: 4745072 (1988-05-01), Ekins et al.
Dans et al (1980) Microbiology 3rd Ed, Harper & Row, Philadelphia, pp. 326-328.
Spencer CA. J. Endocrinol. Invest. 9 (Suppl. 4) 1986, pp. 57-66.
Alexander, NM. Clin. Chem. 32 (3), 1986, p. 417.
Nucker Christine M.
Preston David R.
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