Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1998-10-23
2000-07-04
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514176, 514177, 514178, 514182, A61K 3158
Patent
active
060839406
ABSTRACT:
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat androgen-related clinical conditions are provided, as are methods and compositions for using the compounds as contraceptive agents.
REFERENCES:
patent: 4150127 (1979-04-01), Anner et al.
patent: 4412993 (1983-11-01), Sokolowski
patent: 4456600 (1984-06-01), Wiechert et al.
patent: 4558041 (1985-12-01), Wiechert et al.
patent: 4673673 (1987-06-01), Laurent et al.
patent: 4874754 (1989-10-01), Nique et al.
patent: 4891365 (1990-01-01), Wiechert et al.
patent: 4892867 (1990-01-01), Wiechert et al.
patent: 4925834 (1990-05-01), Bohlmann et al.
R.A. Edgren et al. (1966), "Biological Effects of Synthetic Gonanes," Recent Progress in Hormone Research 22:305-341.
Ferrari et al. (1980), "Endocrine Profile of Topterone, a Topical Antiandrogen, in Three Species of Laboratory Animals," Meth and Find Exptl Clin Pharmacol 2(2):65-69.
S. Nakajin et al. (1989), "Inhibitory Effect and Interaction of Stanozolol with Pig Testicular Cytochrome P-450 (17.alpha.-Hydroxylase/C.sub.17,20 -Lyase)," Chem. Pharm. Bull.37(7):1855-1858.
G. Ohta et al. (1965), "Investigations on Steroids. IV. Syntheses of Androstano[2,3-c]-furazans and Related Compounds," Chem. Pharm. Bull. 13:1445-1459.
T. Ojasoo et al. (1987), "Towards the Mapping of the Progesterone and Androgen Receptors," J. Steroid Biochem. 27(1-3):255-269.
L.L. Smith (1966), "Absorption Spectra of Substituted .DELTA..sub.4 -3-Ketosteroids in Concentrated sulfuric Acid. III 19-Nor Series," Tex. Reports Biol. Med. 24(4):674-692.
C.H. Spilman et al. (1985), "Relationaship between Progesterone Receptor Binding and Progestin Biological Activity," J. Steroid Biochem. 22(3):289-292.
K. Tanayama et al. (1979), "Disposition and Metabolism of 16.beta.-Ethyl-17.beta.-Hydroxy-4-Estren-3-One (TSAA-291), a New Antiandrogen, in Rats," Steroids:65-83.
K. Ueno et al. (1967), "Investiagion on Steroids. VIII. Synthesis of Steroidal [2,3-c]furazans of Pregnane Series," Chem. Pharm. Bull. 15(4):523-527.
Chao Wan-Ru
Chong Wesley K. M.
Crowe David F.
Tanabe Masato
Cook Rebecca
Reed Dianne E.
SRI - International
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