Chemistry: physical processes – Physical processes – Crystallization
Patent
1979-12-28
1981-03-17
Marcus, Michael
Chemistry: physical processes
Physical processes
Crystallization
252408, 422 80, 423405, 23230PC, 23230M, 23927, G01N 3100, G01N 3300, C01B 2124
Patent
active
042564620
ABSTRACT:
N-nitrosamines are reacted with a denitrosating agent to cleave the N--NO bond and yield nitric oxide which may be analyzed to determine both qualitatively and quantitatively, the N-nitrosamine content of a test sample. The denitrosating reagent has the advantage of being useful, even in the presence of substantial amounts of water, and comprises a mixture of glacial acetic acid and a concentrated inorganic acid which is either phosphoric acid or sulfuric acid. The volume ratio of glacial acetic to concentrated acid is within the ratio of from 1:2 to 5:1. This acid component mixture is combined with from about 0.1% to about 5% by weight of soluble inorganic bromide or iodide salt.
REFERENCES:
patent: 3647387 (1972-03-01), Benson et al.
patent: 3973910 (1976-08-01), Fine
G. Eisenbrand et al., Arzneim-Forsch, 20, 1513 (1970).
Drescher et al., Anal. Chem. 50, 2118-2121 (1978)-Estimation of Extractable N-Nitroso Compounds at the Parts-per-Billion level.
N-Nitroso Compounds Analysis and Formation, Bogovski et al. IARC Scientific Publication No. 3 (1971) 140 pages.
Cox Robert D.
Frank Clyde W.
Nord Paul J.
Marcus Michael
University of Iowa Research Foundation
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