Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1999-08-20
2000-06-06
Witz, Jean C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
435 405, 435 4051, 4352401, C07C 4500
Patent
active
060720867
ABSTRACT:
A method and composition for quenching formaldehyde fixation of cell and tissue specimens. The composition includes a formaldehyde-reactive agent. The formaldehyde-reactive agent reacts with the formaldehyde to quench the fixation of the cell or tissue specimen. The method involves contacting a formaldehyde fixative solution with the composition.
REFERENCES:
patent: 2544944 (1951-05-01), Ferrari, Jr.
patent: 3197302 (1965-07-01), MacBride et al.
patent: 3862300 (1975-01-01), Wertlake et al.
patent: 3896033 (1975-07-01), Grimm, III
patent: 3912490 (1975-10-01), Boghosian
patent: 4687489 (1987-08-01), Rieke et al.
patent: 4871549 (1989-10-01), Ueda et al.
patent: 5108621 (1992-04-01), Robins
patent: 5186732 (1993-02-01), Thompson et al.
patent: 5244787 (1993-09-01), Key et al.
patent: 5260048 (1993-11-01), Ryan
patent: 5478722 (1995-12-01), Caldwell
patent: 5597977 (1997-01-01), Chattopadhyay
patent: 5609870 (1997-03-01), Michael et al.
patent: 5637319 (1997-06-01), Takada
patent: 5648222 (1997-07-01), Tse et al.
Greer et al. Sample Preparation and PCR Amplification from Paraffin-Embedded Tissues; PCR Methods and Applications; pp. 113-115, 1994.
Leong, A. and Gilham P. The Effects of Progressive Formaldehyde Fixation on the Preservation of Tissue Antigens; Pathology vol. 21 pp. 266-268, 1989.
Ishino, et al., "Design and preparation of pulsatile release tablet as a new oral drug delivery system", Chem. Pharm. Bull. (Tokyo), vol. 40, No. 11 (Nov. 1992), p. 3036. (Abstract only).
Narisawaa, et al., "An organic acid-induced sigmoidal release system for oral controlled-release preparations", Pharm. Res., vol. 11, No. 1 (Jan. 1994), p. 111. (Abstract only).
Yoshino, "Design and evaluation of time-controlled oral drug delivery system", Membrane, vol. 19, No. 6 (1994), p. 392 (Abstract only).
Narisawa, et al., "Drug release behavior in gastrointestinal tract of beagle dogs from multiple unit type rate-controlled or time-controlled release preparations coated with insoluble polymer-based film", Journal of Controlled Release, vol. 33, No. 2 (1995), p. 253. (Abstract only).
Narisawa, et al., "An orgnanic acid-induced sigmoidal release system for oral controlled-release preparations. 2. Permeability enhancement of Eudragit RS coating led by the physicochemical interactions with organic acid", J. Pharm. Sci., vol. 85, No. 2 (Feb. 1996), p. 184. (Abstract only).
Narisawa, et al., "An organic acid-induced sigmoidal release system for oral controlled-release--system for oral controlled release preparations: III. Elucidation of the anomalous drug release behavior through osmotic pumping mechanism",International Journal of Pharmaceutics (Amsterdam), vol. 148, No. 1 (1977), p. 85. (Abstract only).
Ueda, et al., "Development of a novel drug release system, time-controlled explosion system (TES)", Journal of Drug Targeting, vol. 2, No. 1 (1994), p. 35. (Abstract only).
Ueda, et al., "Development of a novel drug release system, time controlled explosion system (TES): II. Design of multiparticulate TES and in vitro drug release properties", Chemical & Pharmaceutical Bulletin (Tokyo), vol. 42, No. 2 (1994), p. 359. (Abstract only).
Ueda, et al., "Development of a novel drug release system, time-controlled explosion system (TES): III. Relation between lag time and membrane thickness", Chemical & Pharmaceutical Bulletin (Tokyo), vol. 42, No. 2 (1994), p. 364. (Abstract only).
Ueda, et al., "Development of a novel drug delivery system, time-controlled explosion system (TES). IV. In vivo drug release behavior", J. Drug Target, vol. 2, No. 2 (1994), p. 133. (Abstract only).
Kimura, et al., "Development of time-controlled explosion system (TES)", Membrane, vol. 20, No. 4 (1995), p. 263. (Abstract only).
Takaya, et al., "Importance of dissolution process on systemic availability of drugs delivered by colon delivery system",Journal of Controlled Release, vol. 50, Nos. 1-3 (1998), p. 111. Abstract only).
Bankfalvi, et al., "Wet Autoclave Pretreatment For Antigen Retrieval In Diagnostic Immunohistochemistry", Journal of Pathology (1994), vol. 174, p. 223. (First page only).
Battifora, "Assessment of antigen damage in immunohistochemistry. The vimentin internal control", Am. J. Clin. Pathol., vol. 96, No. 5 (1991), p. 669. (Abstract only).
Battifora, et al., "The Influence of Protease Digestion and Duration of Fixation on the Immunostaining of Keratins", The Journal of Histochemistry and Cytochemisty, vol. 34, No. 8 (1986), pp. 1095-1100.
Cattoretti, et al., "Antigen Unmasking On Formalin-Fixed, Paraffin-Embedded Tissue Sections",, Journal of Pathology vol. 171 (1993), pp. 83-98.
Clark, et al., Staining Procedures, Williams & Wilkins (Baltimore/London), 4th Ed. (1981), pp. 11-23.
Elias, et al., "Quality control immunohistochemistry. Report of a workshop sponsored by the Biological Stain Commission", Am. J. Clin. Pathol., vol. 92, No. 6 (1989), p. 836. (Abstract only.).
Feldman, "Reactions of Nucleic Acids and Nucleoproteins with Formaldehyde", Progress In Nucleic Acid Research and Molecular Biology, Academic Press (New York/London), vol. 13 (1973), pp. 1-49.
Fox, et al., "Formaldehyde Fixation", The Journal of Histochemistry and Cytochemistry, vol 33, No. 8 (1985), pp. 845-853.
Greer, et al., "Sample Preparation and PCR Amplification from Paraffin-embedded Tissues", Cold Spring Harbor ISSN, vol. 3 (1992), pp. S113-S115.
Huang, et al., "Application of immunofluorescent staining on paraffin sections improved by trypsin digestion", Lab Invest., vol. 35, No. 4 (Oct. 1976), p. 383. (Abstract only).
Karlsen, et al., "Modifications of human and viral deoxyribonucleic acid by formaldehyde fixation", Lab Invest., vol. 7, No. 4 (Oct. 1994), p. 604. (Abstract only).
Leong, et al., "The Effects of Progressive Formaldehyde Fixation on The Preservation of Tissue", Pathology, vol. 21 (1989), pp. 266-268.
Mason, et al., "Effects of formaldehyde fixation on protein secondary structure: a calormetric and infrared spectroscopic investigation", J. Histochem. Cytochem., vol. 39, No. 2, (Feb. 1991), p. 225. (Abstract only).
O'Leary, et al., "The importance of fixation procedures on DNA emplate and its suitability for solution-phase polymerase chain reaction and PCR in situ hybridization", Histochem J., vol. 26, No. 4 (Apr. 1994), p. 337. (Abstract only).
Overton, et al., "Method to Make Paraffin-Embedded Breast and Lymph Tissue Mimic Fresh Tissue in DNA Analysis", Cytometry, vol. 26 (1996), p. 166. (First page only).
Overton, et al., "Reversing the effect of formalin on the binding of propidium iodide to DNA", Cytomety, vol. 16, No. 4 (Aug. 1, 1994), p. 351. (Abstract only).
Shi, et al., "Antigen Retrieval in Formalin-fixed, Paraffin-embedded Tissues: An Enhancement Method for Immunohistochemical Staining Based on Microwave Oven Heating of Tissue Sections", The Journal of Histochemistry and Cytochemistry, vol. 39, No. 6 (1991), pp. 741-748.
Shi, et al., "Antigen Retrieval Immunohistochemistry: Past, Present, and Future", The Journal of Histochemistry &Cytochemisty, vol. 45, No. 3 (1997), pp. 327-343.
Silvestrini, et al., "Immunohistochemical Detection of p53 in Clinical Breast Cancers: a Look at Methodologic Approaches", Journal of the National Cancer Institute, vol. 87, No. 13 (Jul. 5, 1995), p. 20.
O'Leary, et al., "The importance of fixation procedures on DNA template and its suitability for solution-phase polymerase chain rection and PCR in situ hybridization", Histochem J., vol. 26, No. 4 (1994), p. 337 (Abstact only).
Walker, "Paraformaldehyde", Formaldehyde, Reinhold Publishing (New York) (1994), pp. 69, 70, 73.
Walker, "Chemical Properties of Formaldehyde", Formaldehyde, Reinhold Publishing (New York) (1944), pp. 102-116.
Walker, "Reactions of Formaldehyde with Inorganic Agents", Formaldehyde, Reinhold Publishing (New York) (1944), pp. 117-137.
Walker, "Reactions with Amino and Amino Compounds", Formaldehyde, Reinhold Publishing (New York) (1944), pp. 208-226.
Walker, "Hexamethylenetetramine", Formaldehyde, Reinhold Publishing (New York) (1944), pp. 276-284, 296.
Baker, Controlled Release of Biologically Active Agent, John Wi
Hoag Stephen W.
James William M.
Intergen Company
Witz Jean C.
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