Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1989-03-14
1992-12-08
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
424450, 558408, A01N 3734
Patent
active
051698650
ABSTRACT:
A method, and mediating agents are provided for mediating the physiological effects of hormones, neurotransmitters, calcium-channel antagonists, chemotactic peptides or chemotactic proteins. The mediating agents provided herein are bioactive conformations of peptide hormones, neurotransmitters, calcium-channel antagonist drugs or chemotatic peptides, or analogues, agonists or antagonists thereof, or synthetic analogue substances, having Ca.sup.2+ and/or Mg.sup.2+ ions optimally and optimally-conformationally bound to the respective compound. The Ca.sup.2+ antagonist/agonist may bind Mg.sup.2+ and thus may also block calcium-channel. In the one method, the concentration of intracellular Ca.sup.2+ is raised by means of such mediating agents. A second method is also provided for delivering Ca.sup.2+ and/or Mg.sup.2+ to a membrane-bound receptor by transporting Ca.sup.2+ and/or Mg.sup.2+ through a cell membrane using the above-described mediating agents.
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Cooper Iver P.
Kraus E. J.
Lee Lester L.
Seabright Corporation Limited
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