Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-10-17
2006-10-17
Harris, Alana M. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S385000, C530S386000, C530S387700, C530S388100, C530S387300, C530S388220, C530S360000, C530S389100, C530S391100, C530S391700, C530S391900, C514S001000, C514S002600, C514S008100, C536S001001, C536S018700, C536S022100, C536S023100
Reexamination Certificate
active
07122635
ABSTRACT:
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple helical forms of the collagen. Antagonists of the invention can target, for example, denatured collagens type-I, type-II, type-III, type-IV, type-V and combinations thereof. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo. Antagonists include monoclonal antibodies referred to as HUI77, HUIV26, and XL313.
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Brooks Peter C.
Petitclerc Eric
Xu Jingsong
Harris Alana M.
Hogan & Hartson LLP
University of Southern California
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