Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-12-31
1994-02-15
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514921, A61K 31715
Patent
active
052867188
ABSTRACT:
A method of inhibiting tissue damage in warm blooded animals related to reperfusion of tissues after extended periods of ischemia is presented. The method comprises treatment prior to a planned ischemic event or up to six hours after an unplanned ischemic event with an effective amount of monophosphoryl lipid A or 3-deacylated monophosphoryl lipid A. Pharmaceutical compositions for the treatment are also disclosed.
REFERENCES:
patent: 4436727 (1984-03-01), Ribi
patent: 4912094 (1990-03-01), Myers et al.
patent: 4976959 (1990-12-01), Berger, Jr. et al.
patent: 4985241 (1991-01-01), Zimmerman et al.
Ambrosio, et al. Circulation, vol. 76, No. 4, pp. 906-915 (Oct. 1987).
Ding, The Journal of Immunology, vol. 141, No. 7, pp. 2407-2412, Oct. 1, 1988.
Beckman et al., Proct. Natl. Acad. Sci. USA, vol. 87, pp. 1620-1624, Feb. 1990.
Asayama, et al. Am. J. Physiol., 249 (Cell Physiol. 18): C393-C397 (1985).
Berg, et al. J. Appl. Psysiol., 68(2):549-553 (1990).
Allison, et al. J. Appl. Physiol. 69(2) 1990.
Berg, et al. Proc. Soc. Exp. Biol. & Medicine, 193:167-170 (1990).
Welbourn, et al. The Journal of Immunology, vol. 145, 1906-1911, No. 6 (Sep. 15, 1990).
Mullane, et al. The Journal of Pharmacology and Experimental Therapeutics, Col. 228, No. 2 (1984).
Nelson, et al. Surgery, 110:2 (Aug. 1991).
Wendel, et al. Biochemical Pharmacology, vol. 36, No. 16, pp. 2637-2639 (1987).
Entman, et al., The FASEB Journal, vol. 5, pp. 2529-2537 (Aug. 1991).
Braunwald et al., J. Clin. Invest., vol. 76, Nov. 1985, 1713-1719.
Bensard, et al., Journal of Surgical Research, vol. 48, No. 6, Jun. 1990.
Brown, et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 2516-2520, Apr. 1989.
Brown, et al., Proc. Natl. Acad. Sci. USA, vol. 87, pp. 5026-5030, Jul. 1990.
Woodward et al., J. Mol. Cell Cardiol. 17, 485-493 (1985).
Weishaar, et al., Journal of Molecular and Cellular Cardiology, 12, 993-1009 (1980).
Jolly, et al. Journal of Cardiovascular Pharmacology, 4:441-448 (1982).
Jolly, et al., Circulation Research, vol. 54, No. 3, pp. 277-285 (Mar. 1984).
Heiman, et al., J. Lab Clin. Med., pp. 237-241 (Aug. 1990).
Bensard, et al. "Endotoxin Induces Left Ventricular Depression In the Isolated Perfused Rat Heart" Submitted AJP Apr. 27, 1990.
Abstract: Heiman et al., Clinical Research, vol. 36, No. 6, p. 847A (1988).
Abstract: Hirose, et al., Macrophage Biology III, A1854:939 1988.
Abstract: Nicolini, et al., JACC, vol. 25, No. 2, Feb. 1990:32A 1987.
Abstract: Hale et al., JACC, vol. 26, No. 2, Feb. 1990:32A 1987.
Abstract: Simpson, J. Lab. Clin. Med., 110(1) pp. 13-30 (Jul. 1987).
Abstract: Simpson, Fed. Proc. 46(7) pp. 2413-2421 (May 15, 1987).
Elliott et al., "The D-Galactosamine Loaded Mouse and Its Enhanced Sensitivity to LPS and Monosphosphoryl Lipid A: A Role for Superoxide" (Running Title: Factors of Galactosamine Sensitization to MPL) 1990.
Hook Gregory
Ribi ImmunoChem Research Inc.
Waddell Frederick E.
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