Method and composition for achieving cancer chemopreventive and

Details Method and composition for achieving cancer chemopreventive and Method and composition for achieving cancer chemopreventive and

1989-11-13

1991-03-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514578, 514725, A61K 3120, A61K 3107

Patent

active

049978527

ABSTRACT:
The present invention describes a protocol for achieving a very high degree of anticarcinogenic (chemopreventive and chemotherapeutic) activity through the combination of low suboptimal doses of a D-glucarolactone-based dietary anticarcinogen with low suboptimal doses of a retinoid-based anticarcinogen. Synergism is obtained by this combination and these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.

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Oredipe et al., Cancer Letters, 1987; 38:95-99.
Walaszek et al., Carcinogenesis, 1984; 5:767-772.
Walaszek et al., IRCS Medical Science, 1986; 14:677-678.
Levvy, Biochem. J., 1952; 52:464-472.
Moon et al., The Retinoids, vol. 2, New York:Academic Press, 1984; 327-371.
Hixson et al., Toxicol. Appl. Pharmacol., 1979; 47:359-365.
Abou-Issa et al., Biochem. Biophys. Res. Comm., 1986; 135:116-123.
Welsch et al., Diet, Nutrition, and Cancer, 1986; (B. S. Reddy and L. A. Cohen eds.) CRS Press, Boca Ratyon, Fla., pp. 1-21.
Schamberger, Diet, Nutrition, and Cancer, Diet, Nutrition, and Cancer, (B. S. Reddy and L. A. Cohen eds.) CRS Press, Boca Raton, Fla., pp. 43-62 (1986).
Moon et al., Cancer Res., 1976; 36:2626.
Matsui et al., Chem. Pharm. Bull., (Tokyo) 1972; 20:845-848.
Swanson et al., J. Pharmacol. Exptl. Therap., 1981; 219:632-637.
Abou-Issa et al., Biochem. and Biophys. Res. Comm., Sep. 29, 1989, 163:1364-1369.

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