Method and composition for achieving anticarcinogenic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514613, A61K 31185

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active

050101072

ABSTRACT:
The present invention describes a protocol for achieving a very high degree of anticarcinogenic (or chemopreventive or cancer preventative) activity through the combination of a low suboptimal dose of a D-glucarolactone-based dietary anticarcinogen (i.e., calcium glucarate or CGT) with a low suboptimal dose of retinoid-based anticarcinogen (4-hydroxyphenyl retinamide or HPR). Since synergism is obtained by this combination, these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.

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Welsch et al., Diet, Nutrition, and Cancer, (B. S. Reddy and L. A. Cohen eds.) CRS Press, Boca Raton, FL pp. 1-21 (1986).
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Ip et al., Carcinogenesis, 2:435-438 and 915-918 (1981).
McCormick et al., Cancer Res. 40:1140-1143 (1980).

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