Method and article to induce hematopoietic expansion

Details Method and article to induce hematopoietic expansion Method and article to induce hematopoietic expansion

1998-04-30

1999-09-07

Saunders, David

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 424484, 424486, 424 937, 435373, 435372, 435374, 435395, 435405, 514 8, A61F 228, A61K 919, A61K 3818, C12N 508

Patent

active

059484268

ABSTRACT:
An article and method to create retrievable sites of implantable and transplantable bone marrow, in a human or animal recipient, by implanting bone-marrow inducing conjugates of collagen and demineralized freeze-dried bone allograft (DFDBA) into accessible soft or hard tissue sites is provided. The implantation of such collagen-DFDBA conjugate grafts into suitable ectotrophic sites results in the formation of bone-marrow and hematopoietic tissue within the implant. By removing all or a portion of the bone marrow containing areas of the implant, an additional source of hematopoietic tissue and bone marrow cells is formed which can subsequently be transplanted into the same individual as an autograft, or a related or compatible individual as an allograft.

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