Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means
Reexamination Certificate
2008-02-23
2010-12-21
Vanore, David A (Department: 2881)
Radiant energy
Ionic separation or analysis
Cyclically varying ion selecting field means
C250S281000, C250S288000, C250S291000, C250S292000, C250S294000
Reexamination Certificate
active
07855360
ABSTRACT:
A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
REFERENCES:
patent: 6495823 (2002-12-01), Miller et al.
patent: 6498342 (2002-12-01), Clemmer
patent: 6559441 (2003-05-01), Clemmer
patent: 6784424 (2004-08-01), Willoughby et al.
patent: 6794641 (2004-09-01), Bateman et al.
patent: 6806463 (2004-10-01), Miller et al.
patent: 6815668 (2004-11-01), Miller et al.
patent: 6822224 (2004-11-01), Guevremont
patent: 6960761 (2005-11-01), Clemmer
patent: 7015466 (2006-03-01), Takats et al.
patent: 7164122 (2007-01-01), Fuhrer et al.
patent: 7228091 (2007-06-01), Hays et al.
patent: 7518108 (2009-04-01), Frey et al.
patent: 7521673 (2009-04-01), Arcas et al.
Casado Alejandro
de la Mora Juan Fernandez
Fernandez de la Mora Gonzalo
Hoffmann & Baron , LLP
Sociedad Europea de Analisis Diferencial de Movilidad
Vanore David A
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