Method and apparatus suitable for ocular blood flow analysis

Optics: measuring and testing – Photometers – Photoelectric

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128654, 128745, G01J 142

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active

042498252

ABSTRACT:
Glaucoma and other diseases may be detected by the analysis of angiograms to determine ocular blood flow. Using rapid sequence photography an ocular image is recorded on successive film frames. To determine the optical density of the film at selected image sites, the image position on the frames being subject to change from frame to frame, each frame is initially positioned manually at a starting position relative to a density sensing system. Then, X-Y stepping motors move the film under control of a digital processor to position the film frame at each selected image site. A detector is insensitive to light from a viewing optical system because of a filter included in that system. A crosshair image-point indicator is included on a filter in the viewing system.

REFERENCES:
Ben-Sira, I and Riva, C., "Fluorophotometric Recording of Fluoroscein Dilution Curves in Human Retinal Vessels", Investigative Ophthalmology, vol. 12, No. 4, Apr. 1973, pp. 310-312.
Bullpitt, C. J. and Dollery, C. T., "Estimation of Retinal Blood Flow by Measurement of the Mean Circulation Time," Cardiovascular Research, vol. 5, pp. 406-412 (1971).
Fonda, S. and Bagolini, B., "Relative Photometric Measurements of Retinal Circulation (Dromofluorograms)", Arch. Opthalmology, vol. 95, Feb. 1977, pp. 302-307.
Hickam, J. B. and Frayser, R., "A Photographic Method for Measuring the Main Retinal Circulation Time Using Fluoroscein," Investigative Opthalmology, vol. 4, Oct. 1965, pp. 876-884.
Hickam, J. B. and Frayser, R., "Observations on Vessel Diameter, Arteriovenous Oxygen Difference and Mean Circulation Time," Circulation, vol. XXXIII, Feb. 1966, pp. 302-316.
Read, J. S. et al., "Measurement of Mean Retinal Circulation Time with a Computer-Controlled Television Ophthalmoscope Image Processor," Arvo Abstract, p. 226.
Riva, C. E. et al., "Fluoroscein Dye-Dilution Technique and Retinal Circulation," Am. J. Physiol. 243(3): H315-H433, 1978.

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