Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1998-10-16
2000-11-07
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
436 47, 436807, 436809, 209214, 210222, 210695, 4352871, 4352872, 4352873, 422 65, 422 681, 422101, 422102, G01N 33553, G01N 3502, B03C 100, B01D 3506, C12M 100
Patent
active
061435783
ABSTRACT:
Method and apparatus for enabling resuspension wash and magnetic localization of sample components bound to particles with magnetic properties in reaction vessels during separation and wash for enhanced chemiluminescent signal generation in biomedical assays. The assays involve moving reaction vessels past magnets that partially localize the particles prior to passing a reduced strength magnet where washing occurs, with or without resuspension, after separating out the unbound particles and liquid. The band of particles is subsequently resuspended in acid for chemiluminescent purposes. A variety of magnet configurations are employed to realize the reduced strength magnet. Reduced strength magnets adjacent the full width magnets prevent the band of magnetic particles from becoming split. The localized particles enable more efficient resuspension by reagent.
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Bendele Teresa M.
Harrison Linda A.
Howard David J.
Knotts Lori K.
Malek Michael L.
Bayer Corporation
Chin Christopher L.
Do Pensee
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