Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1996-05-10
1999-03-30
Wolski, Susan
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
209214, 210695, 210222, 422 65, 4352871, 4352872, 4352873, 436 47, 436807, 436809, G01N 33553
Patent
active
058888357
ABSTRACT:
Method and apparatus for enabling resuspension wash and magnetic localization of sample components bound to particles with magnetic properties in reaction vessels during separation and wash for enhanced chemiluminescent signal generation in biomedical assays. The assays involve moving reaction vessels past magnetic arrays that partially localized the particles prior to passing a gap where washing occurs, with or without resuspension, after separating out the unbound components and liquid. The band of particles is further localized by a focusing magnet at the end of the array prior to dosing the vessel with acid for chemiluminescent purposes. A block of soft magnetic material is employed in place of a magnet in the gap to minimize magnetic strength at the gap. Trimmed magnets adjacent the gap cause left, then right, particle shifting that localizes the magnetizable particles. The gap enables improved resuspension by wash, whereas the localized particles enable more efficient resuspension by reagent.
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Bushnell Steven E.
Garyantes Tina K.
Kirchick Howard J.
Malek Michael L.
Blackburn Robert P.
Chiron Diagnostics Corporation
Gagnebin , III Charles L.
Morgenstern Arthur S.
Wolski Susan
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