Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1997-05-15
2000-02-15
Casler, Brian L.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
324309, A61B 5055
Patent
active
060263164
ABSTRACT:
The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
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Kucharczyk John
Moseley Michael E.
Casler Brian L.
Regents of the University of Minnesota
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