Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1997-05-15
2000-05-09
Casler, Brian L.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600411, 600431, 600432, 600433, 604 21, 604 93, 604151, 604152, 604153, 604154, 604155, A61B 505
Patent
active
060615877
ABSTRACT:
The invention is an apparatus and method for targeted drug delivery into a living patient using magnetic resonance (MR) imaging. The apparatus and method are useful in delivery to all types of living tissue and uses MR Imaging to track the location of drug delivery and estimating the rate of drug delivery. An MR-visible drug delivery device positioned at an target site (e.g., intracranial delivery) delivers a diagnostic or therapeutic drug solution into the tissue (e.g., the brain). The spatial distribution kinetics of the injected or infused drug agent are monitored quantitatively and non-invasively using water proton directional diffusion MR imaging to establish the efficacy of drug delivery at a targeted location.
REFERENCES:
patent: 3640269 (1972-02-01), Delgado
patent: 4448195 (1984-05-01), LeVeen et al.
patent: 4572198 (1986-02-01), Codrington
patent: 4694832 (1987-09-01), Ungerstedt
patent: 4767973 (1988-08-01), Jacobsen et al.
patent: 4807620 (1989-02-01), Strul et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 4827931 (1989-05-01), Longmore
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 4922924 (1990-05-01), Gambale et al.
patent: 4941874 (1990-07-01), Sandow et al.
patent: 4973304 (1990-11-01), Graham et al.
patent: 4989608 (1991-02-01), Ratner
patent: 5017566 (1991-05-01), Bodor
patent: 5035231 (1991-07-01), Kubokawa et al.
patent: 5087236 (1992-02-01), Morimoto
patent: 5106455 (1992-04-01), Jacobsen et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5120322 (1992-06-01), Davis et al.
patent: 5135498 (1992-08-01), Kam et al.
patent: 5154179 (1992-10-01), Ratner
patent: 5167625 (1992-12-01), Jacobsen et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5211165 (1993-05-01), Dumoulin et al.
patent: 5211166 (1993-05-01), Sepponen
patent: 5226902 (1993-07-01), Bae et al.
patent: 5269882 (1993-12-01), Jacobsen
patent: 5270485 (1993-12-01), Jacobsen
patent: 5271400 (1993-12-01), Dumoulin et al.
patent: 5273622 (1993-12-01), Jacobsen
patent: 5318025 (1994-06-01), Dumoulin et al.
patent: 5318540 (1994-06-01), Athayde et al.
patent: 5375596 (1994-12-01), Twiss et al.
patent: 5419325 (1995-05-01), Dumoulin et al.
patent: 5451774 (1995-09-01), Jacobsen
patent: 5470307 (1995-11-01), Lindall
patent: 5487739 (1996-01-01), Aebischer et al.
patent: 5514092 (1996-05-01), Forman et al.
patent: 5569197 (1996-10-01), Helmus et al.
patent: 5571089 (1996-11-01), Crocker
patent: 5573668 (1996-11-01), Grosh et al.
patent: 5580575 (1996-12-01), Unger et al.
patent: 5588961 (1996-12-01), Leone et al.
patent: 5590654 (1997-01-01), Prince
patent: 5607418 (1997-03-01), Arzbaecher
patent: 5704908 (1998-01-01), Hofmann et al.
patent: 5713359 (1998-02-01), Dumoulin et al.
patent: 5800392 (1998-09-01), Racchini
patent: 5800408 (1998-09-01), Strauss et al.
patent: 5868674 (1999-02-01), Glowinski et al.
Beucker, A., et al., "First clinical results with a single shot zoom imaging sequence "local Look" for high resolution subsecond interventional MR procedures", Proceedings of the International Society for Magnetic Resonance in Medicine, Fifth Scientifc Meeting and Exhibition, Vancouver, BC, Canada, vol. 2, p. 779, (Apr. 12-18, 1997).
Boaz, T.L., et al., "A rabbit model for MR-monitoring of tissue destruction in MR-guided radiofrequency hepatic thermal ablation", Proceedings of the International Society for Magnetic Resonance in Medicine, Fifth Scientific Meeting and Exhibition, Vancouver, BC, Canada, vol. 2, p. 774, (Apr. 12-18, 1997).
Burl, M., et al., "A novel coil for catheters for guide wires", Robert Steiner MRI Unit, Hammersmith Hospital, London, W12 ONN, UK, p. 403.
Coutts, G.A., et al.,"Integrated position tracking and imaging of interventional tools and internal devices using small fiducial receiver coils", Proceedings of the International Society for Magnetic Resonance in Medicine, Fifth Scientific Meeting and Exhibition, Vancouver, BC, Canada, vol. 3, p. 1924, (Apr. 12-18, 1997).
Gohde, S.C., et al., "MR-guided cholecystostomy in a pig: assessment of biplanar, real-time Needle Tracking", Proceedings of the International Society for Magnetic Resonance in Medicine, Fourth Scientific Meeting and Exhibition, New York, USA, vol. 2, p. 892, (Apr. 27-May 3, 19).
Langsaeter, L., et al., "Tracking of an MR-compatible Microendoscope for Interventional MRI of the Paranasal Sinuses", UMDS Radiological Sciences, Guy's Hospital, London, SE1 9RT, UK, p. 1929.
Lu, D., et al., "MR-guided percutaneous ethanol ablation of liver tissue in a 0.2T open MR System: preliminary STudy in Porcine Model", Proceedings of the Internatinal Society for Magnetic Resonance in Medicine, Fourth Scientific Meeting and Exhibition, New York, USA, vol. 2, p. 894, (Apr. 27-May 3, 19).
McKinnon, G., "Tracking and Monitoring the Effects of Interventional MR instruments", Proceedings of the Society of Magnetic Resonance, Third Scientific Meeting and Exhibition, and the European Society for Magnetic Resonance in Medicine and Biology, Twelfth Annual Meeting and Exhibition, Nice, France, p. 490, (Aug. 19-25, 1995).
Melzer, A., et al., "Methodology, Technological Prerequisites and Preliminary Clinical Results of Interventions in a Horizontal Open MRI Unit", Proceedings of the International Society for Magnetic Resonance in Medicine, Fourth Scientific Meeting and Exhibition, New York, USA, vol. 2, p. 897, (Apr. 27-May 3, 19).
Rosen, B.R., et al., "Perfusion Imaging by Nuclear Magnetic Resonance", Magnetic Resonance Quarterly, vol. 5, No. 4, pp. 263-281, (1989).
Zimmermann, G.G., et al., "Evaluation of Catheter/Guide wire steerability: in vitro comparison of fluoroscopic guidance with active MR-tracking in an open 0.5R MR-system", Proceedings of the International Society for Magnetic Resonance in Medicine, Fifth Scientific Meeting and Exhibition, Vancourver, BC, Canada, vol. 3, p. 1930, (Apr. 12-18, 1997).
Bouvier, G., et al., "Direct Delivery of Medication into a Brain Tumor through Multiple Chronically Implanted Catheters", Neurosurgery, 20, No. 2, 286-291, (1987).
Chandler, W.F., et al., "Use of Implantable Pump Systems for Intraarterial, Intraventricular and Intratumoral Treatment of Malignant Brain Tumors", Ann. N.Y. Acad. Sci., 531, 206-212, (1988).
Gillies, G.T., et al., "Magnetic manipulation instrumentation for medical physics research", Rev. Sci. Instrum., 65(3), 533-562, (1994).
Hajnal, J.V., et al., "MR Imaging of Anisotropically Restricted Diffusion of Water in the Nervous System: Technical, Anatomic, and Pathologic Considerations", J. of Computer Assisted Tomography, 15(1), 1-18, ((1991).
Hurst, G.C., et al., "Intravascular (Catheter) NMR Receiver Probe: Preliminary Design Analysis and Application to Canine Iliofermoral Imaging", Mag. Res. Med., 24, 343-357, (1992).
Johnston, J., et al., "Shiley Infusaid Pump Technology", Ann. N.Y. Acad. Sci., 531, 57-65 (1988).
Kucharczyk, J., et al., "Differential effects of brain lesions on thirst induced by the administration of angiotensin-II ot the preoptic region, subfornical organ and anterior third ventricle", Brain Res., 108, 327-337, (1976).
Moseley, M.E., et al., "Magnetic resonance imaging of diffusion and perfusion", Top Mag. Reson. Imaging, 3(3), 50-67, (1991).
Schmitt, F.O., "Molecular Regulators of Brain Function: A New View", Neuroscience, 13, 991-1001, (1984).
Sendelbeck, S.L., et al., "Spatial Distribution of Dopamine, Methotrexate and Antipyrine During Continuous Intracerebral Microperfusion", Brain Res., 328, 251-258, (1985).
Swanson, L.W., et al., "Autoradiographic Evidence for Pathways from the Medial Preoptic Area to the Midbrain Involved in the Drinking Response to Angiotensin II", J. of Comparative Neurology, 178, No. 4, 645-659, (1978).
Wimberger, D.M., et al., "Identification of "Premyelination" by Diffusion-Weighted MRI", J. of Computer Assisted Tomography, 19(1), 28-33, (1995).
Kucharczyk John
Moseley Michael E.
Casler Brian L.
Regents of the University of Minnesota
LandOfFree
Method and apparatus for use with MR imaging does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for use with MR imaging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for use with MR imaging will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1074028