Method and apparatus for the production of secondary metabolites

Details Method and apparatus for the production of secondary metabolites Method and apparatus for the production of secondary metabolites

1977-07-13

1979-09-11

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Condition responsive control process

435244, 435289, 435311, 435813, 435818, 435802, C12D 100, C12D 300, C12B 100

Patent

active

041674502

ABSTRACT:
A fermentation vessel is used to grow a cell mass and maintain it in a maintenance energy state. In this state the mass of the cell material is maintained substantially constant, and fresh medium containing an energy source is introduced to the vessel at a rate sufficient to sustain cell viability but insufficient to support growth of the cell mass. Fluid with suspended cells is pumped from the vessel to a separator which separates a fraction of the fluid from the cells and discharges the fraction, the unfiltered portion of the fluid and substantially all of the cells being returned to the vessel, the discharged fraction containing useful secondary metabolites.

REFERENCES:
patent: 2822319 (1958-02-01), Monod
patent: 3015612 (1962-01-01), Pirt et al.
patent: 3252870 (1966-05-01), Braun et al.
patent: 3418208 (1968-12-01), Coty
patent: 3472765 (1969-10-01), Budd et al.
patent: 3647632 (1972-03-01), Johnson et al.
patent: 3822187 (1974-07-01), Du Chaffaut
patent: 3915802 (1975-10-01), Kominek
patent: 3926737 (1975-12-01), Wilson et al.
Bu'Lock "Secondary Metabolism of Microorganisms", Industrial Aspects of Biochemistry, vol. 30, Spencer ed., North-Holland Co., Amsterdam, (1974), pp. 335-346.

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