Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1994-12-09
1997-06-24
Redding, David A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 11, 4352862, 4352864, 604 19, 604290, C12Q 124, C12M 300
Patent
active
056416440
ABSTRACT:
Disclosed are a method and apparatus for the precise positioning of cells into highly organized tissue structures, which are suitable for use in the treatment of burn patients. Specific placement of cells onto substrata is obtained by the computer-controlled direct placement of cell suspension matrix material, which includes cells suspended by an extracellular matrix material, including cell adhesion proteins, collagens, gelatin (i.e., degraded collagen), and cyanoacrylates or other cellular glues. A fluorescence activated cell sorter is used to provide a stream or droplet stream of the biological material. Cells may also be positioned by means of computer-controlled placement of cell adhesion materials such as fibronectin to a substratum which is suitable for maintaining cell growth, followed by allowing cells to attach to those areas of the substratum where the cell adhesion material has been placed. These apparati may even be further modified and improved by providing a controlled biological environment in the area of the substratum, thus providing an integral unit for the production of organized tissues.
REFERENCES:
patent: 4656130 (1987-04-01), Shoshan
patent: 4664945 (1987-05-01), Maeda et al.
patent: 4791069 (1988-12-01), Hovarka et al.
patent: 4874500 (1989-10-01), Madou et al.
patent: 4877745 (1989-10-01), Hayes et al.
patent: 5108926 (1992-04-01), Klebe
Klemperer, "Electron Optics," UMI Books on Demand, Second Edition, 1953.
Klebe et al., "Fibronectin-Mediated Attachment of Mammalian Cells to Polymeric Substrata," Chapter 38 of Proteins at Interfaces, ACS Symposium Series 343, eds. Brush and Horbett, pp. 615-628, 1987.
Klebe et al., "Adhesive Substrates for Fibronectin," Journal of Cellular Physiology, 109:481-488, 1981.
Klebe, "Cytoscribing: A Method for Micropositioning Cells and the Construction of Two-and Three-Dimensional Synthetic Tissues," Experimental Cell Research, 179:362-372, 1988.
Board of Regents , The University of Texas System
Redding David A.
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